1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Dr. Kerr, I presume?
Clark Ellis brings us a rare interview with British researcher Dr. Jonathan Kerr who is now living in Colombia.
Discuss the article on the Forums.

geneticgenie progress for interpretation fo 23andMe results

Discussion in 'Genetic Testing and SNPs' started by kday, Sep 23, 2012.

  1. kday

    kday Senior Member

    Messages:
    260
    Likes:
    48
    For those interested, I am still working on this. I have someone writing interpretation of results that's much more qualified than myself. As far as changing around the SNPs for the methylation pathway, I don't see how you could do this without clinical experience. I don't know how Amy Yasko got all her information, but I think a lot of it probably came from clinical experience rather than published articles.

    23andMe just opened their API too. What does this mean? It will make it a lot easier for you and I. You won't have to upload your data anymore. It'll just work as long as your logged into 23andMe. And thanks to those who donated. The site will be updated when it's ready.
     
    merylg and camas like this.
  2. Gamboa

    Gamboa Senior Member

    Messages:
    195
    Likes:
    162
    Canada
    This sounds good but I don't really understand it all. I went to the 23andMe website but I can't get a clear answer about how much it all really costs. They mention $299 to order the kit but what happens then? Do you pay a lot more money to actually get the results? It also mentions a subscription but I couldn't find out what that meant. Do you know what the actual cost of an analysis would be? Thank you,

    Gamboa
     
  3. caledonia

    caledonia

    Messages:
    3,039
    Likes:
    1,711
    Cincinnati, OH, USA
    The 23andme stuff is separate from what Kday is talking about. You register with the site and pay 23andme $299. They'll mail you a test kit. You spit in the plastic tube to give them a saliva sample, then mail it back. Then you wait a couple weeks and you'll get an email saying your results are ready.

    You go to the 23andme.com, and look at your results. They have various health results like "you have a slightly increased risk for X disease", and various traits like "your eyes are likely blue". They also have ancestry results like "you're 90% Eastern European and 10% Asian." 23andme tests for several hundred thousand gene SNPs.

    Right now, before paying them, you can go to their website and register. This will allow you to view the sample data of the Mendel family (nicknamed after famous early geneticist Gregor Mendel, get it?). You can see all of the health data, traits and ancestry for each member of the family.

    Ok, now for Kday's Genetic Genie page. You take your results from 23andme and plug it into Kday's analyzer. It will pick out about 25 SNPs which are the same as Yasko's methylation panel. Then it will display a nifty color chart similar to the results you would get from Yasko. The worst double mutations will display red, the single mutations will display yellow, and normal genes will display green. The red and yellow SNPs are the ones you will need to address.

    Right now you will need to interpret the chart yourself using Yasko's book or the Heartfixer page.

    Kday indicates that he has someone working on their interpretation of the chart, and that in the future, this will print out along with your chart.

    Kday is also working on the SNPs which are similar to the Genova Detoxigenomics Detox panel (showing SNPs in the phase I and phase II detox pathways). You can get an interpretation of this by using the Genova Detoxigenomics sample report.

    ps. the subscription from 23andme means that they'll email you for the next year with any updates about your genes. The field is still very new, so there are constantly new findings regarding genes. They'll keep you up to date about this.
     
    merylg, Hanna and camas like this.
  4. kday

    kday Senior Member

    Messages:
    260
    Likes:
    48
    Thank you caledonia for explaining everything!
     
  5. ahmo

    ahmo Senior Member

    Messages:
    1,423
    Likes:
    1,017
    Northcoast NSW, Australia
    I've just discovered GeneticGenie, just ordered 23andme. I'm also pretty new to PR, have been reviewing many methylation threads. Now I know that you're responsible for this great program. Thank You. !
     
  6. roxie60

    roxie60 Senior Member

    Messages:
    1,728
    Likes:
    539
    Central Illinois, USA
    23andme just received 3 NIH grants worth over $500,000. Wish they could lower the price for a bit to people.
     
  7. roxie60

    roxie60 Senior Member

    Messages:
    1,728
    Likes:
    539
    Central Illinois, USA
    anyone know if 23andme reduces their prices around Christmas? I know they lowered it to $99 in April of 2011, I just do not know if this was a rare offering or if they offer discounts a various times during the year?
     
  8. roxie60

    roxie60 Senior Member

    Messages:
    1,728
    Likes:
    539
    Central Illinois, USA
    You all probably know by now my Christmas wish was answered in less than 7 days - 23andMe testing available now for $99 vs $299, plus S&H. I gave a shout of joy and id a little dance (not too much)
     
    Hanna likes this.
  9. greenshots

    greenshots Senior Member

    Messages:
    399
    Likes:
    139
    California
    Thank you Kday! I'll be sure to steer friends and family to use your genie and donate something too!
     
  10. kday

    kday Senior Member

    Messages:
    260
    Likes:
    48
    Thanks. I am making some modifications to my site. I don't know when I'll put the new version and detox SNPs up since I've been feeling so crappy (and can't sleep).

    greenshots - While donations are appreciated to keep the site running, I don't want anyone to feel obligated. I know first-hand how much of a financial drain this illness can be.
     
    roxie60 likes this.
  11. leela

    leela Slow But Hopeful

    Messages:
    2,459
    Likes:
    3,024
    Couchland, USA
    thanks for making that powerful wish, roxie! i have been pestering them here and there abut a price cut since i missed the one in 2011, and getting rather stupid beaurocratic answers back. looks like your method was most effective :thumbsup:
     
  12. leela

    leela Slow But Hopeful

    Messages:
    2,459
    Likes:
    3,024
    Couchland, USA
    sorry you've been feeling crappy, kday. me too. :(
    but soon i shall get my kit and find my way over to your genie. thanks so much for making it.
    feel better soon!
    (((kday)))
     
  13. kday

    kday Senior Member

    Messages:
    260
    Likes:
    48
    This is really exciting... A genetic risk test based on 65 SNPs is out for Autism and is currently being tested by the Cleveland Clinic.

    It has 65 SNPs, and 23andMe as every single one of them.

    How this will help ME/CFS? I have no clue. I'd be very curious if we have high "Autistic" scores as I feel Autism and CFS may have a very similar genetic setup. And if this turns out not to be true, it can help the Autism community.

    http://www.arisktest.com/28-understanding-the-report.htm
     
    merylg, roxie60 and anne_likes_red like this.
  14. Aileen

    Aileen Senior Member

    Messages:
    608
    Likes:
    493
    Canada
    kday, where are you getting 65 SNPs? I clicked on your link, but there was only 38 in their sample report. Is there another article with more information? I'm going to check my 23andMe results out of curiosity and to see just what these SNPs are.
     
  15. kday

    kday Senior Member

    Messages:
    260
    Likes:
    48
    You're right Aileen. Those SNPs only apply to males. And I can't find a female sample test. There is a total of 65 SNPs between the male/female test if I remember right.

    I am working on an Autism Risk feature. All it outputs is a meaningless table right now with no score, but if anyone wants to help me out by uploading their data and email me their results, it would be appreciated.

    I am trying to figure out if the risk alleles I had to change around are all correct, and I am trying to figure out how they did their calculations. Or if someone can figure it out how they did their calculations for me, that would be awesome.

    PM me and I'll send you a link if you want to help out. You can be female, but for risk assessment for this specific test, it's only applicable to males.
     
    Anteah and merylg like this.
  16. kday

    kday Senior Member

    Messages:
    260
    Likes:
    48
    Full list of SNPs

    http://www.integragen.fr/upload/Documents/ARISk Test SNPs.pdf

    edit: It turns out their methods (using SNPs) for assessing autism risk are patented, so I don't know how much I could do with it. I am kind of wandering in the gray zone though so I don't really know how patent laws would apply to me.
     
    LaurieL and merylg like this.
  17. merylg

    merylg Senior Member

    Messages:
    764
    Likes:
    494
    Sydney, NSW, Australia
    Interesting thanks kday. GRIN2A is interesting. I have two copies of T. What does "additive" mean, as opposed to "dominant" or "recessive" ?

    http://en.m.wikipedia.org/wiki/GRIN2A#section_3
     
  18. merylg

    merylg Senior Member

    Messages:
    764
    Likes:
    494
    Sydney, NSW, Australia
  19. merylg

    merylg Senior Member

    Messages:
    764
    Likes:
    494
    Sydney, NSW, Australia
  20. merylg

    merylg Senior Member

    Messages:
    764
    Likes:
    494
    Sydney, NSW, Australia

See more popular forum discussions.

Share This Page