Had a quick look at that study. The TNF Alpha stuff seems to be predominantly about
mice, and I couldn't see anything about PPAR Gamma.
No point going to a UK doctor about genetic results - waste of time. Info from
Scion/CellF and Nutrametrix says:
- ACE deletion in intron 16: bp increase; alterations in levels of total cholesterol and plasma triglycerides; reduction in insulin sensitivity. Advice: exercise, reduce carbs, correct BMI.
- eNOS G894T: less nitric oxide, so less smooth muscle relaxation; reduced platelet activity. Advice: increase omega-3 intake.
- GSTM1 deleted: compromised Phase II detoxification and antioxidant activity.
- GSTP1 A313G and C341T: reduced AO/detox activity.
- IL-6 G(-174)C but not G(-634)C: increased inflammation but less than if both variations present; undefined implications for heart/cardiovascular health and bone; presumably reduced insulin sensitivity as listed in insulin sensitivity results section as well.
- PPARγ2 Pro12Ala: associated with lower BMI, improved insulin sensitivity and higher HDL levels - I like this one!
- TNF-α G(-308)A: poss. excess inflammation due to increased levels/activity; undefined implications for heart/cardiovascular health and bone health; presumably reduced insulin sensitivity as listed in insulin sensitivity results section as well
- VDR Fok1: reduced calcium absorption due to reduced Vitamin D response