Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Genetic (SNP) Influence onThyroid Function tests

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by roxie60, Aug 23, 2013.

  1. roxie60

    roxie60 Senior Member

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    Has anyone made progress identifying SNPs that can affect thryroid function tests? If o please post the gene, SNPs and risk alelles if you know them. I found this study that has attempted to determine the impact of some SNPs on thyroid tests which I find interesting, did not think that our genes might affect test results.

    This thread can be a collection point for those interested in collecting SNP info as it relates to thyroid, or anything HPA axis/ endo related. My curiosity is due to the fact that for so many years my tests rarely seem to show anything of diagnostic value so I am starting to wonder if my genes maybe affecting th test results.

    9781441914842-c2.pdf
     
  2. Valentijn

    Valentijn Activity Level: 3

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    Not yet. But my sexy new rare allele program did show that I'm homozygous for a very rare allele which causes a missense mutation at rs10776792 on the TSHB gene (thyroid stimulating hormone) :cool:

    No research into that one, unfortunately. My TSH tested at pretty normal levels: 2.250 with a reference range of 0.4 - 4.0. However, sometimes levels can be normal, if the substituted amino acid is not extra heat-sensitive, while the protein is still not functioning properly.
     
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  3. roxie60

    roxie60 Senior Member

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  4. roxie60

    roxie60 Senior Member

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    What is the rare/risk alelle for this SNP? Some research suggests TSH over 2.0 can leave a person feeling poorly.
     
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  5. Valentijn

    Valentijn Activity Level: 3

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    A
     
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  6. roxie60

    roxie60 Senior Member

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  7. roxie60

    roxie60 Senior Member

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