Hi All.. Newbie here. I wanted to ask a few questions. I wanted to ask for any insights, help, as I learn more and more of genetics. I wanted to ask if someone could possible help me to marry the organic acid test, with genetic results. Which markers connect to possible snps. Im still learning about snps, methylation etc. It's all new. The Organic Acid test from Great Plains, gives lots of details on the report, what to take to help, but I'm just trying to put the puzzle together with the genetic snp. A short summary of the report states : reveals the inability to metabolize the proteins leucine, lysine, tryptophan, hydroxylysine due to enzyme deficiencies, mitochondrial dysfunction, and bacterial overgrowth. Adrenal fatigue and low serotonin levels are suspected. Test result ------------------------ Possible Indications Slightly High Glyceric -- -- Genetic marker Slightly High Oxalic -----Excess oxalates High Fumaric -----Mitochondrial dysfunction High 3-Methylglutaric ------Leucine metabolism/mitochond Slightly High 3-Hydroxyglutaric -----Glutaryl CoA deficiency Slightly High 3-Methylglutaconic -----Leucine metab/mitochon Slightly Low Vanillylmandelic (VMA) ------Adrenal fatigue High HVA/VMA Ratio -------Adrenal fatigue Slightly Low 5-Hydroxyindoleacetic (5-HIAA) -------Slightly low serotonin High Quinolinic/5-HIAA Ratio -------Adrenal fatigue/tryptophan High Uracil ------Folic acid deficit High 3-Hydroxybutyric ------Protein malnutrition/B12 High Acetoacetic ------Protein malnutrition/B12 High Adipic ------Gelatin/”junk food” additive Slightly High Suberic -----Ketogenic diet Low Pyridoxic (B6) -----Low vitamin B6 Slightly Low Pantothenic (B5) -----Slightly low vitamin B5 Slightly Low Ascorbic ------Slightly low vitamin C Low N-Acetylcysteine (NAC) ------Low NAC-antioxidant High 2-Hydroxybutyric -------Enzyme deficit Slightly High 2-Hydroxyhippuric -------Aspirin/aspartame Now my genetic results from the Yasko website were : RS4680 COMT V158M +/- RS4633 COMT H62H +/- RS731236 VDR Taq TT RS2228570 VDR Fok ff RS6323 MAO A R297R +/+ RS1801133 MTHFR C677T +/- RS1805087 MTR A2756G +/+ RS567754 BHMT 2 +/+ RS651852 BHMT 8 +/- RS234706 CBS C699T +/- RS1801181 CBS A360A +/- However the longer more detailed report I received from a different source, does not show the VDR Fok, or Taq TT. Shows normal. I have read about this, find it a bit confusing... But another snp that wasnt tested from the Yasko site was the NOS snp, which was NOS2 (rs2297518) +/+ NOS2 (rs2274894) +/+ NOS2 (rs2248814) +/+ NOS3 (rs1800779) +/+ NOS3 (rs3918188) +/- NOS3 D298E (rs1800783) +/+ Im still learning so Im not sure which is most significant. I also had many ACAT ++, etc. But I guess the ones Yasko lists are more significant etc. Alright, any puzzle piecing would be appreciated.