Hello! I'm pretty new to this community, but I've recently come across it and admired the collection of information and support. I've recently been researching my SNPs and found a lot of connections between what I feel and some of the researched symptoms of people with my mutations. My main symptoms include: Brain fog Fatigue Less "agile" or "sharp" thinking Depression/anxiety Oversleeping and unfulfilled sleep Overall feeling of being on a mental deficit Incorporating a lifestyle of exercise, proper diet and sleep hygiene has helped, but because of the recent research I've done on my genetics, I'd really like to address some of these mutations and supplement the deficits caused by them. Here's my methylation analysis from genetic genie: http://i.imgur.com/XmDWYvp.png Here's my nutrahacker detox report: https://www.nutrahacker.com/detoxRe...omer_376d1a95-eacd-4a34-ad23-1648f35dceb1.pdf My confusion stems from my COMT and VDR mutations. I've been supplementing 1mg b12 sublingual methylcobalamin and 450mcg 5-MTHF everyday for the past 2 weeks and haven't noticed any large improvements. Although there may be other factors to this, I've actually been feeling subtly worse at times and slightly better at other times. I've also been supplementing 1,000 IU of vitamin D3 everyday for my deficiency (which most likely has something to do with VDR Taq +/+). According to Yasko Methylation, VDR taq should also make me less sensitive to methyl group supplement levels (http://www.snpedia.com/index.php/Yasko_Methylation#VDR_Gene). But, according to my nutrahacker report, my COMT mutation should make me less tolerant to methyl B12 and methyl groups. Should I just supplement hydroxycobalamin instead? Thanks!