So as the subject suggests I was wondering whether or not the mentioned tests are worth it? Also a few general questions below.... I am currently taking 3,000mcg (with approx 3,000mg potassium) of methylfolate which I know is a high dose, actually 5,000mcg is the dose that causes healing which I cannot tolerate so 3,000mcg seems just right. I have not noticed any benefit from taking 400mcg or 800mcg methylfolate. I am concerned I may have a genetic mutation somewhere. I am currently trying to support BH4 production which I feel has been semi successful as my mood has lifted slightly after getting to the high doses of methylfolate. I am going to add in folinic acid to see if it helps with the BH4 and thus my mood. Is folinic acid necessary when already supplementing methylfolate? I know Fredd would say avoid it...! There is a test I have read about from Vitamin Diagnostics called the 'Methylation Panel'. Does anyone have any experience with this? And was it worth it? The genetic tests available to me are the two tests available from Genova Diagnostics NeuroGenomic™ Profile and DetoxiGenomic® Profile. I do not know if Yasko accepts test samples from the UK shipped to the USA. I want to get to the bottom of my problems without ad hocking supplementation as I feel lost. I don't know whether genetics or the methylation panel is the answer. I am still chelating heavy metals so I know that to some degree the methylation cycle is going to be poisoned.