@caledonia It has come to my attention that you are knowledgeable with interpreting Genetic Genie Results and SNP's. I've watched the Methylation made easy videos, studied heartfixer, SNPedia, as well as many other sites that my head spins! My next goal is to study the SNP Interpretation guide. What I've learned about myself is that I have the A198C gene which means that i have a 20% reduction in methylation, but can cause issues with BH4 production? I havn't studied BH4 yet. So, with this not sounding as serious as having the MTHFR C677T gene, I should still supplement methyfolate for this? On that note of methylfolate, I also have the MAOA R297R gene which I understand does not tolerate methylfolate well, should I be worried about that when treating my A198C mutation? I currently supplement extra R5P for MAO A R297R. What else can I do about it? With COMT i have COMT V158M +/- and COMT H62H +/- with VDR TAQ +/+. I've read that this combination makes my COMT behave as -/- and that means I should tolerate methyl groups well. I've also read that with this combination of SNP's I can experience fluctuations with dopamine levels. I supplement around 5000 iud Vitamin D for VDR TAQ, with the hopes I am on the right track to controlling those fluctuation I am sure i experience. Next is MTR, MTRR mutations. These ones came simple to me that they just require Methyl B12 supplementation. What do you think? I've took little note of my CBS mutations, as I have found they are not as important as once thought. Thank you for looking over this.