The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Genetic Genie Results. Any Help Would be Appreciated

Discussion in 'Genetic Testing and SNPs' started by Murpcmnz, Dec 17, 2015.

  1. Murpcmnz

    Murpcmnz

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    Hi Guys,

    Just got my 23andme results back. Any help or recommendations would be appreciated

    Homozygous:

    MAO A R297R
    MTRR A664A

    Heterozygous:

    VDR Bsm
    VDR Taq
    MTRR A66G
    BHMT-08
    CBS C699T

    Thanks
     
  2. Murpcmnz

    Murpcmnz

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    My homocysteine is high (13) but my MMA is low indication that my B12 is fine but it sounds like the MTRR indicates I need B12?
     
  3. Valentijn

    Valentijn Senior Member

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    No, that MTRR variation has very little impact. Your SNPs listed here look quite normal.

    Other MTRR and MTHFR mutations are listed at:
    http://forums.phoenixrising.me/index.php?threads/interesting-mtrr-variations.24551/
    http://forums.phoenixrising.me/index.php?threads/interesting-mthfr-variations.24543/

    Typically only missense mutations will have a significant impact on function.
     
  4. Murpcmnz

    Murpcmnz

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    Thank you very much for your response. I had an HDRI panel done and waiting on those results but any speculation why homocysteine would be so high with mostly normal genes?
     
  5. Valentijn

    Valentijn Senior Member

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    Avoiding meat and/or vegetables might cause low folate or B12, which I suppose might result in high homocysteine.

    But there are also hundreds of other SNPs on the MTHFR gene and MTRR gene which are not tested by 23andMe - it's possible there is some dysfunction elsewhere on those genes.
     

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