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Yes, keep the p5p low if you feel the need to add it. Reiterating the b2 needed for balance. Greenshots gave you a good plan and explanation.
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I do have TMG as well...
So molybdenum first, then TMG?
I thought the b vits would come last, but you think I should take b12 now?
I don't have hydroxo. That is better for my type?
My general history is that I crashed a couple years back after impartial recovery from a stomach virus.
Since then I have had most of the CFS symptoms and was diagnosed with Lyme. I am looking for ways to make sure I can detox properly so I can go after the lyme.
"I guess the bottom line is that instead of adding in B-12 and methylfolate right away, its about getting the basics like B complex,"
I'm confused here as I thought people with MTHFR could not tolerate normal B-complex w/ folic acid etc.
There's probably no cause to worry about them. The only relevant BHMT result is BHMT-08 in those results, and the only relevant CBS result is 699T in those results. And with those being heterozygous, any impact is likely to be minimal. If the actual test of sulfur levels shows it isn't a problem, then it's best to go with that.So after testing my urine at home numerous times it seems like sulphur load is already in the target range as mentioned on the heartfixer page. Does this mean I should not worry about BHMT and CBS?
There's probably no cause to worry about them. The only relevant BHMT result is BHMT-08 in those results, and the only relevant CBS result is 699T in those results. And with those being heterozygous, any impact is likely to be minimal. If the actual test of sulfur levels shows it isn't a problem, then it's best to go with that.
Remember that TMG is a big methyl so I'm not sure it would be wise to start that right off the bat and skip all the others. Caledonia and I have listed several basic things that most people seem to need. The methyls come later. As for Juniemarie adding yucca, or butyrate, or something else, this really depends on how sick you are, whether you need more gut support, and other factors. I don't see how those two would hurt though. I guess the bottom line is that instead of adding in B-12 and methylfolate right away, its about getting the basics like B complex, digestive enzymes, antioxidants, some minerals, and stuff like that on board before you start methylation up. Usually, B-12 and methylfolate go together for best effects but the dosing is completely different for everyone. I know my doc likes injectables for people with MCS who can't tolerate B12 any other way but uses a variety of types for others. I don't know all that goes into her decision making but it sure is individualized.
" its about getting the basics like B complex, digestive enzymes, antioxidants, some minerals, and stuff like that on board before you start methylation up."
I have taken a B complex for about 6 months out of the past year. I have been doing digestive enzymes, vit c, vit e, magnesium, vit d, and fish oil (amongst other things) for the past year.
I can't say that I notice any specific benefit or marked improvement from any of these. They all might help in very minute ways, but I need to find something that makes a real difference.
If my urine sulphur levels are in the target range, again, why am I fooling around with months of treating CBS and BMHT with diet and more expensive supplements? There are many treatments out there to consider and as you know you can't so them all at once so I need to find out which ones are relevant and which ones aren't.
For all I know, I could follow every single step for each POSSIBLE snp and get nowhere slowly.
I am asking for objective measures of weighing which ones I should work on, but you are not clarifying things in that department. I am not interested in chasing mirages.
Bloopy, These are from previous discussions in this same thread
More recent post
Remember that TMG is a big methyl so I'm not sure it would be wise to start that right off the bat and skip all the others. Caledonia and I have listed several basic things that most people seem to need. The methyls come later. As for Juniemarie adding yucca, or butyrate, or something else, this really depends on how sick you are, whether you need more gut support, and other factors. I don't see how those two would hurt though.
PLEASE READ: I guess the bottom line is that instead of adding in B-12 and methylfolate right away, its about getting the basics like B complex, digestive enzymes, antioxidants, some minerals, and stuff like that on board before you start methylation up. Usually, B-12 and methylfolate go together for best effects but the dosing is completely different for everyone. I know my doc likes injectables for people with MCS who can't tolerate B12 any other way but uses a variety of types for others. I don't know all that goes into her decision making but it sure is individualized.
First post about this from this thread
P5P isn't good right now cuz of the CBS, but maybe you could use low doses of 10mg
DMG shouldn't be used before TMG. You have to get the short route up and running with the BHMTs before you can fix the MTRR problem.
I'd say molyb sounds right and you need basic B vitamins and digestive enzymes to start. Then maybe a little hydroxy B 12 and vit c for free radicals. Then maybe some low dose SAMe to get rolling a little more. Unless your super type A and sympathetic dominant, niacin will just eat up more methyls so I'm not sure about even adding that one.
The goal is clean up not fixing the genes just yet. If you go after the genes first, you make more garbage. And when were sick, were already overflowing with garbage. This is the reason Yasko has so many foundation sups so there is a method to her madness although i don't think you need that whole list she gives. I think Caledonia may have some good input here. Remember that we dn't know who you are or what you've been thru or been exposed to so this changes things too. I would start low and go slow on some more benign stuff before your dumping in a bunch of methyls.