Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
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Genetic ADHD - Might you have it?

Discussion in 'General Treatment' started by xks201, Oct 7, 2012.

  1. xks201

    xks201 Senior Member

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    How many of you had ADHD before developing full blown CFS/FM?

    Dopmaine excites the pituitary, the master gland, to signal most of the hormones in the body. It would be a good idea if you have the money to do a genetic test on 23andme (or some place that can test ADHD genes). ADHD is real ... literally dopamine just leaks out of the membrane backwards when it should be moving forwards. Let me find the article...http://www.dnalc.org/view/2393-Treating-ADHD-with-Amphetamine-.html

    I've had ADHD since a kid. I've also had frequent urination though from time to time. I don't know what preceeded what but I have heard of a urologist who attempts to restore pituitary hormones by giving people amphetamine to stimulate the pituitary by stimulating more dopamine.

    I used to be one of those people that did not believe in ADHD. IT IS REAL. These scientists are showing dopamine just leaking out of the vesicles. lol Then we have some CFS docs using dopamine agonists to treat ADHD and finding low levels of dopamine in most CFS/FM patients. Could it be that they were just long undiagnosed with ADHD? Dopamine is calming and without it every stimulus hits the brain. Hormones are calming. Having a normal healthy blood volume is calming compared to being hypovolemic. In all of the cases of deficiencies of adrenaline overshoots and we have nervous exhaustion. Could it all be from a genetic predisposition to low dopamine to begin with?
     
    Ocean likes this.
  2. nanonug

    nanonug Senior Member

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    Here's some additional food for thought: Mast Cell What?

    From one of the links on this page:

    "One of the Mast cells functions is regulating dopamine by releasing the neuropeptide (organic brain chemical) neurotensin. Neurotensin has many effects, one of which is decreasing Dopamine. The mast cells can release more of less neurotensin to decrease or increase dopamine and a dysfunction of the mast cells will throw off dopamine levels."

    This is one reason I keep recommending people to test for mast cell disorders and to take stuff such as Wellbutrin.
     
  3. xks201

    xks201 Senior Member

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    Why would wellbutrin help? To increase dopamine? Adderall is better for that I'd think?
     
  4. nanonug

    nanonug Senior Member

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    There are two things I dislike about stimulants (such as Adderall or Ritalin):
    • One can get hooked on that stuff - getting hooked on anything is always a bad idea, in my opinion.
    • The crashes that one gets when the effect wares off. I know this very well given that my son has ADHD and took Adderall in the past.
    Bupropion (Wellbutrin) is a dopamine/norepinephrine reuptake inhibitor. It takes longer (a few weeks) to work but doesn't have any of the two problems above. Same goes for atomoxetine (Strattera) although this one is just a norepinephrine reuptake inhibitor.
     
  5. kday

    kday Senior Member

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    SNPs?
     
  6. *GG*

    *GG* Senior Member

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  7. xks201

    xks201 Senior Member

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    that's funny...and all along I thought all those people complaining about generic drugs were crazy.
     
  8. nanonug

    nanonug Senior Member

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  9. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I have found that when i have taken antidepressants that i notice effects straight away which makes sense as they do increase the intended neurotransmitter straight away. I think the 1-2 weeks to take effect on depression is more related to possible the changes somewhere else in the brain(maybe neurogenisis) but not on the effects on increasing certain neurotransmitters.
     
  10. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Has anyone had success with 'mucuna pruriens' to help increase dopamine levels??
     
  11. nanonug

    nanonug Senior Member

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    I tried it. As in all things amino acid-based, it only works the first few days. Then, the body just gets used to it.
     
  12. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    do u throw it into the mix once in awhile and still get an effect? acety l tyrosine i have had similar experiences but good if use it when u need a pick up.
     
  13. nanonug

    nanonug Senior Member

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    Honestly, I just prefer Wellbutrin! :)
     
  14. Ocean

    Ocean Senior Member

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    I have ADHD and have mostly been unmedicated for it my whole life other than a few short trials of meds. Recently I tried Adderall again, just for one day, and the crash I had afterward was absolutely horrendous. For me, the medicine did not go well with my CFS. I can't get rid of the condition, but using some cognitive and behavioral techniques does help me manage them a little.
     
  15. SickOfSickness

    SickOfSickness Senior Member

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  16. nanonug

    nanonug Senior Member

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    This happens to everybody, not just you (my son included.) In my opinion, it is better to go for non-stimulant medications such as extended-release guanfacine (Intuniv), extended-release bupropion (Wellbutrin XL) or atomoxetine (Strattera). They all take a couple of weeks for full effect but there are no crashes to worry about.
     
  17. Lae

    Lae

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    Hi, not sure if this is of any use to you but my brother has ADHD (the worst case the specialist had ever seen when he was diagnosed back in the 90's) and I have ME.

    ADHD is indeed real. Anyone who says otherwise has never spent 10 minutes alone with someone who has it!
     
  18. nanonug

    nanonug Senior Member

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    Indeed!
     
  19. Ocean

    Ocean Senior Member

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    It doesn't happen to everyone like what I experienced. I know because it never happened to me like that till I got very sick with CFS. Previously I never crashed liked that and my usual CFS crashes are also nothing like that.
     
  20. Ocean

    Ocean Senior Member

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    Antidepressants like Wellbutrin come with their own set of problems, they aren't totally harmless, at least for some people.
     

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