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Genes of interest found in Kerr's 2008 study

Discussion in 'Latest ME/CFS Research' started by WillowJ, Oct 2, 2011.

  1. WillowJ

    WillowJ Senior Member

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    WA, USA
    from:
    Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SC, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST. "Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis." J Infect Dis. 2008 Apr 15;197(8):1171-84. PMID: 18462164

    http://jid.oxfordjournals.org/content/197/8/1171.long

    Table listing the genes
    http://jid.oxfordjournals.org/content/197/8/1171/F8.expansion.html

    I started to look up the genes under the neurology section while looking for something. I don't understand why most of them were classified that way (of the ones I found so far), but I did find the information fascinating. Of course, everything is fascinating to me, but that's another story. :Retro smile:

    gene with known disease associations:

    APP - Alzheimer disease;

    GNAS is actually endocrine - McCune-Albright Syndrome & progressive osseous heteroplasia;

    TNFRSF1A seems inflammatory - tumor necrosis factor receptor-associated periodic syndrome (TRAPS) http://ghr.nlm.nih.gov/condition/tumor-necrosis-factor-receptor-associated-periodic-syndrome persistent fevers, fascinating stuff

    NKFB1 -
    http://atlasgeneticsoncology.org/Genes/NFKB1ID323.html

    that's as far as I got for now, as I determined this paper wasn't relevant to what I'm working on
    L'engle likes this.
  2. Enid

    Enid Senior Member

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    Very interesting - thanks for find WillowJ.
  3. ukxmrv

    ukxmrv Senior Member

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    London
    Thanks Willow, I was one of the patients who gave blood for this study so when it was published I went through and looked up as many of the genes as I could find. In the last few years there will have been lots more information added and I had forgotten all about this.

    Dr Kerr was also interested in trying experimental treatments, also clinical trials. A real tragedy they got rid of him.

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