Genes of interest found in Kerr's 2008 study

[WillowJ]

from:
Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SC, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST. "Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis." J Infect Dis. 2008 Apr 15;197(8):1171-84. PMID: 18462164

http://jid.oxfordjournals.org/content/197/8/1171.long

Table listing the genes
http://jid.oxfordjournals.org/content/197/8/1171/F8.expansion.html

I started to look up the genes under the neurology section while looking for something. I don't understand why most of them were classified that way (of the ones I found so far), but I did find the information fascinating. Of course, everything is fascinating to me, but that's another story. :Retro smile:

gene with known disease associations:

APP - Alzheimer disease;

GNAS is actually endocrine - McCune-Albright Syndrome & progressive osseous heteroplasia;

TNFRSF1A seems inflammatory - tumor necrosis factor receptor-associated periodic syndrome (TRAPS) http://ghr.nlm.nih.gov/condition/tumor-necrosis-factor-receptor-associated-periodic-syndrome persistent fevers, fascinating stuff

NKFB1 -

cancer (see below), autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.

overexpression of nfkb1 has been found in a number of human cancer including non-small cell lung carcinoma, colon cancer, prostate cancer, breast cancer, bone cancer and brain cancer. The rearrangement of nfkb1 gene, however, only has been identified in certain acute lymphoblastic leukemias.

http://atlasgeneticsoncology.org/Genes/NFKB1ID323.html

that's as far as I got for now, as I determined this paper wasn't relevant to what I'm working on

 

[Enid]

Very interesting - thanks for find WillowJ.

 

[ukxmrv]

Thanks Willow, I was one of the patients who gave blood for this study so when it was published I went through and looked up as many of the genes as I could find. In the last few years there will have been lots more information added and I had forgotten all about this.

Dr Kerr was also interested in trying experimental treatments, also clinical trials. A real tragedy they got rid of him.