I know I'm preaching to the choir to some, but this may be helpful information to others. I was reading a transcript of Chris Kresser's about lab testing, and he mentioned the following about methylation: "I know I’ve talked about this before, but it’s a pet peeve of mine when practitioners just test for genetic mutations and start supplementing people only based on those mutations. That’s because a mutation of a gene does not alone imply dysregulation of that gene. It means there’s probably a greater likelihood that the enzyme that the gene produces won’t function well, but it’s not a guarantee. You can have people with genetic mutations in the methylation pathway but their methylation works perfectly well, and you can have people who have no mutations, or really minor mutations, in the methylation pathway that have serious methylation problems. So genes load the gun and environment pulls the trigger." "...factors like diet and lifestyle, toxic exposure, et cetera, are far more important in terms of determining methylation status, which is why I always use a functional methylation profile that tests for patients’ actual methylation capacity. That’s with a lab called Health Diagnostics and Research Institute (HDRI). " Source: http://chriskresser.com/which-lab-tests-are-essential I've seen people on here doing the HDRI panel, and it seems logical that you would need to combine that with the SNP's to get the full picture versus just going by the SNP.