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Genes, Infection, Altered Microbiota Lead to Chronic Inflammatory Disease

Discussion in 'Other Health News and Research' started by Gemini, Jan 20, 2016.

  1. Gemini

    Gemini Senior Member

    East Coast USA
    Acute infection can drive long-term immune & microbiota changes leading to chronic inflammatory disease in genetically pre-disposed individuals:


    This is a unified "hit- and-run" model involving genetic & metabolic signals, acute infection ultimately cleared, & "altered" microbiota-- in humans (it would appear)-- leading to chronic inflammatory disease.

    A similar model has been discussed by ME/CFS researchers over the years, incl. Mady Horning.

    Unfortunately the paper is behind a paywall. I'm curious about how prevalent the TLR1 genetic deficiency is; what specific inflammatory diseases the model applies to; and specifics about the treatments: gene deletion and targeted probiotics.

    Wonder if the collaborators at the Univ of Chicago, Argonne Nat'l Laboratory, UCLA & UC-Davis might have any insights into the pathophysiology of ME/CFS?
    rosie26, ScottTriGuy, ahmo and 3 others like this.

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