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Genes Dictate Folate Benefit in Schizophrenia

N

natasa778

Senior Member
Messages
1,774
http://www.medpagetoday.com/Psychiatry/Schizophrenia/37759

Only when the genetic variants were entered into the model was statistical significance reached, the investigators reported...
...

Their findings may be relevant not only for schizophrenia, but also for other conditions such as cardiovascular disease and dementia, where low folate levels appeared to be a risk factor but no benefits were seen with supplementation in large intervention studies.

"The current results suggest that individual differences in folate metabolism related to the presence of common functional genetic variants may have a bearing on treatment outcomes in these other disorders, as well as negative symptoms of schizophrenia," they commented.
Click to expand...

I wonder how many other treatment trials 'failed' simply because individual differences were not taken into account ...
 
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