Thanks Sushi, For your comments. I'm doing well on the MAF314 and no signs of increased ME symptoms when I am taking it. Been a stop and start process for me though as the person who shares it with me goes away a lot.The longest continuous period seems to be about 10 -12 weeks. At the same time I am taking Valtrex and Immunovir. My feeling is that I tend to plateau on the MAF314. As the plateau is better than my pre-MAF functioning that's good. When I don't take the MAF314 I get sick and deteriorate. Was OK for a good while after the first attempt. More recently I have become very poorly with viruses doing the rounds in my community quite quickly and very severely.