Hey guys, I have been struggling with the above for around 5yrs now and have tried almost everything but have been getting worse. I got really bad recently and was prescribed Mirtazapine, this has helped my POTS noticably and my Apiatiate /gastroparesis is also quite/ improved (though still present). I am wondering if you can help me to determine why? I know it blocks the Glyciine part of the alpha 2 adrenergic receptor. This would lead to more nor-epinephrine, dopamine, and serotonin however less would be getting activated in the brain, right? So this would mean more serotonin in the gut which could help with motility. Also since I think I have big problems with excess adrenaline (hyperadrenegic pots) blocking a2 receptor could also potentially help calm my brain down and put it in a rest and digest state (I am also taking propanolol)? Anything I am missing here? Any other theories? Thanks, Sean.