Just wanted to pass on some info I got from Dr. Oz...these things raise serotonin. From what I read saffron helps PMS (which is MY "wired and tired" and over 50 is PMS forever). (I have not tried this yet). If I skip or schlep my supplement regime I get so wired I can't bear it so I have been supplementing defensively my whole life. The Garcinia supposedly also helps against pain. I checked iherb and found a product "Red Lightnig" and one of the reviewers said it helps them against fibromyalgia pain. I am interested in these primarily because I have horrible spells of what I call schlepiness - can't get much done, I think it's depression based. Comes and goes and I want it gone forever so I am looking into serotonin boosters.