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Ganglioside antibody test result

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by merylg, May 1, 2017.

  1. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
    Ganglioside antibody

    GM-1 IgG.....Not Detected
    GM-1 IgM.....Not Detected
    GD-1b IgG....Not Detected
    GD-1b IgM....Not Detected
    GQ-1b IgG....Not Detected
    GQ-1b IgM..* Detected

    My recent result. Would appreciate help with interpreting this. Value any input or discussion. Thanks!
     
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  2. halcyon

    halcyon Senior Member

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    It looks like the significance of anti GQ-1b antibodies of IgM type is not well established. The wikipedia page on antiganglioside antibodies mentions this but there is no reference provided. This paper says:

    MFS being Miller Fisher syndrome, a variant of guillain-barré syndrome, associated with these GQ-1b antibodies.

    Do you have any neuropathy symptoms?
     
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  3. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
    I have throbbing & burning type pain in my cervical-thoracic spine. Progressing profound muscle weakness mainly in face, neck, arms but also generalised weakness & moderate to severe fatigue. Enthesitis & a lot of muscle pain. Fibromyalgia.

    Brain fog & cognitive issues.

    Not much in the way of numbness & tingling. Occasionally in chin area, which a Neuro said some years ago was consistent with my osteoarthritis in neck area.

    CK normal. EMG & NCS normal. MRI Right shoulder showed torn Supraspinatus, torn labrum, mild bursitis, some unknown process on bone?
    No sign of muscle atrophy.
     
  4. halcyon

    halcyon Senior Member

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    Do you know if your total IgM levels are normal?
     
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  5. merylg

    merylg Senior Member

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    As far as I know, yes. It's been awhile since I tested. My usual pattern is normal levels of IgG & IgM... slightly raised IgA.

    I'll probably repeat the Ganglioside Ab test in a few months time, out of interest. Also will ask my Integrative GP if can repeat Immunoglobulin levels.

    Neuro did not think my Ganglioside Ab (IgM) significant & he sees it quite often. Still noted it in my summary letter.

    Thanks for your input & link Halcyon. I've got similar on my Ross River Virus Serology. An Equivocal for IgM only then two months later a Positive for IgM only.
     
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