Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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gamma e tocohpherol and startup symptoms

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by vortex, Jan 25, 2015.

  1. vortex

    vortex Senior Member

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    on my methylation panel, it showed high nitrotyosine which is a result of high peroxynitrite

    Peroxynitrite induces destruction of the tetrahydrobiopterin
    http://www.ncbi.nlm.nih.gov/pubmed/20184376

    so I began taking gamma e tocopherol which quences peroxynitrite and without changing anything else, I started getting an overmethyation startup reaction, trembling, grinding feeling.

    So I am wondering if some of these high doses of methylation supplements like the people taking 2-15mg of methylfolate is an attempt to overcome the destruction of bh4 from peroxynitrite. I wonder why richvank never put this gamma E into his protocol ?

    I guess I will run another methylation panel and see if my nitrotyrosine levels have come down.
     
    Gondwanaland likes this.
  2. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    vortex and picante like this.
  3. PeterPositive

    PeterPositive Senior Member

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    ... this is probably a stupid question, I haven't studied the NO / ONOO cycle yet... but I recall Dr Ben Lynch talking about methylfolate causing a raise in nitric oxide which in turn can worsen inflammation, if it's excessive.

    Am I completely ass-backwards? :D

    I had some problems with methylfolate initially and I recall similar and stronger issues with Arginine, which is also expected to boost NO, probably more than 5-MTHF.
     
  4. drob31

    drob31 Senior Member

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    BH4 is also the rate limiting enzyme for dopamine if I'm not mistaken. Low BH4 and low dopamine conversion?

    High ammonia (because of bacteria, or poor methylation?), leading to high NO, leading to high peroxynitrite which breaks doen BH4, which leads to a decrease in some neurotransmitters.... (hypothesis)
     
  5. vortex

    vortex Senior Member

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    @ahmo have you made any progress since using gamma E? Gamma Tocotrienol is supposed to be 50 times more potent. So I am going to try that in addition to my gamma tocopherol and then re-run my nitrotyrosine levels to see if I am making any progress.
     

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