A Little Poisoning Along the Road to ME/CFS
Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I'd just been dealing with some heavy-duty menopausal issues.
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GABA ,Glutamate for Anxiety,Sleep

Discussion in 'General Treatment' started by arx, Jun 25, 2013.

  1. arx

    arx Senior Member

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    Hi,

    My major symptom is the 'wired and tired' feeling.In fact I experience it in a very extreme degree. Since benzos gave me 'some' relief,but tolerance and withdrawal was hard to deal with, I've been looking into GABA and Glutamate. I understand that both are related.

    Has anyone tried the above? If yes,did it help,and with what dosage?
     
  2. adreno

    adreno on the beach

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    Wired and tired is more likely to be high NE than high glutamate.
     
  3. arx

    arx Senior Member

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    Then how to reduce high norepinephrine?
     
  4. adreno

    adreno on the beach

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    Olive leaf extract can increase NE reuptake, which is often a problem in ME. Many seem to have NE transporter deficiency and OLE helps that. Else there is SSRIs, clonidine/guanfacine and of course the big one: cortisol. Cortisol is needed to control NE.
     
    Emootje and helen1 like this.
  5. Valentijn

    Valentijn Activity Level: 3

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    I get wired and tired, but have low norepinephrine (blood platelets) and high glutamate (urine tests). NAC takes care of it and lets me sleep.
     
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  6. helen1

    helen1 Senior Member

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    What about high sulfur and ammonia levels? They can cause excitotoxicity. Can occur due to the CBS variation. Do you know if you have CBS? Glutamate is related to those. I make sure not to eat any unbound glutamates (as found in MSG and the many similar additives in processed foods) as they're dreadful for causing 'wired n tired' and twitching in the susceptible. Also eat very little or no bound glutamates in the evening for the same reason. Even though bound glutamates (meats, dairy, nuts) have less effect, it still affect can affect sleep.
    Be wary of GABA supplements as I've read they cause decreased production of your own GABA with regular use.
     
  7. arx

    arx Senior Member

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    Will GABA be as effective as a benzo?
     
  8. Nielk

    Nielk

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    The problem with people who have been on Benzo medicines for a long period of time (me being one of them) is that like helen1 mentioned above - your brain "forgets" how to use the GABA it has. You might not be deficient. It might just be a problem of not "knowing" how to use the GABA that is there. By using GABA products, it will just aggravate the situation.

    Ii has been over a year sine I have been on Klonopin (a Benzo med) and I still suffer from this wired feeling. Sometimes it's better and other times it is pretty bad. I too was looking into GABA products in order to ease these symptoms but I have found many warnings against it's use in my situation. It is hard to do but. I really have to allow my brain to heal and to learn to recollect.
     

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