Maybe not Tig Notaro cancer-funny, but pretty good for an academic paper. Results are the same as for CFS, with CBT leading to improvements in questionnaire scores, but not objective measures of illness. They're more open about this being a problem than they were with their CFS results, but still try very hard to avoid mentioning even the possibility that their questionnaires are not reliable measures of outcome for cognitive or behavioural interventions (and succeed!). Full paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360858/ I picked some bits out, but it's quite a short paper, so people might prefer to just read it themselves. Couple of bits making it clear that, if CBT were working as intended, activity levels would increase: Nice they can be certain of this: Looks like the control was waiting list only, so lots of room for response bias. Again they decide to assume that perpetuating factors are entirely reversible and cognitive/behavioural, based on.... wish thinking? (pragmatism): Worth noting that 'top-up' sessions were available in the second six months: For those of you really interested in mediation analyses, there's a fair bit of it, and I'm too tired to dig into that right now (someone explained bootstrapping to me... I understood it for a bit!). No significant relationship between changes in physical function, and changes in fatigue questionnaire scores: I'm going to post all of their discussion, because it's a bit funny to me that they explore so many possibilities, without ever considering whether their highly effective cognitive-behavioural treatment might just be inducing response bias when compared to a waiting list control. We have no evidence that fatigue questionnaires are reliable ways of assessing cognitive and behavioural interventions. Also, they keep trying to come up with ways in which patients could have increased their activity... but that just didn't show up. I thought this might be of interest. PS: Best wishes to all those struggling with cancer or post-cancer fatigue. I ended up on a forum for cancer sufferers who were discussing some research once, and they seemed really pissed off by the way in which their cognitions and behaviours were being medicalised too. For them it was like: 'I've got Cancer! I don't want to have to deal with this shit too! Let me be myself.'