HI, I am doing Fred's protocol and would like to keep a journal so everything is in one spot and I can have feedback. I first got diagnosed with CFS when I was 23. The best the Dr. could do was offer anti-depressants. From there I went on to have 3 children and was noticable more tired by the 3rd. I have been doctoring for the last 5 years trying to figure out what is wrong. I even mentioned to a doctor 4 years ago that I think I need to check out methylation issues. He dismissed it and just wanted to chelate the heavy metals. I think methylation is at the core of my body not functioning right. My health has declined at a fast rate the last 5 years. Here is my first test: I did Health Diagnostics test: March 2012 Gutathione oxidized .51 range .16-.50 Glutathione redued 3.3 range 3.8-5.5 s-adenosylmethionine 237 range 221-256 s-adensoylhomocysteiine 56.8 range 38-49 folic acid derviates 5-CH3-THF 15.0 range 8.4-72.6 10-Formyl-THF 4.3 range 1.5-8.2 5-Formyl-THF 4.90 range 1.2-11.70 THF 1.15 range 06-6.80 Folic Acid 18.5 range 8.9-24.6 Folic Acid (WB) 17-3 range 9.0-.35.5 Folic Aci active RBC 417 range 400-1500 I started with the b-complex a couple of days ago. Today: 200mcg potassium upon waking 200 mcg potassium with breakfast 200 mcg potassium with dinner (will titrate up as needed.) 1 douglas b-complex with metafolin A-10,000 IU--Thompson 4:1 oil by Body Bio ascorbic acid - 9,000mg magnesium chloride oil magnesium sulfate iv-1.5mg at bed E complex by NOW 3/4 tab Metafolate--3 x day and will tytrate up as needed 1/16 tab adb m12 1/2 tab mb12 Phosphatidylcholine iv push every other day. 500mg take unisom at bed time but doesn't seem to help (not taking zinc yet until I get saliva test done on Monday) No D today and no calcium. seeing if they affect my sleep. I fell asleep around 10:00 last night and woke at midnight and did not sleep the rest of the night. I need sleep very bad and it just doesn't come. Hoping that the methylation will fix that. yesterday was similar, but the first day on the mb12. I noticed alertness which was good and I was having these symptoms: Achy muscles,, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Forgetfulness, Confusion, Difficulty walking, I took more methylfolate at lunch and I noticed these were so much beter. I also noticed that my chest muscles are not so tight either. I can breath better. That might be from potassium. It is 2 1/2 hours after breakfast and I am noticing lightheadedness so I will take more metafolate now.