Freddd, please disregard the last convo message i sent to you(not instant message). this is where im at, and what i need figuring now. This isnt just directed at the expert Freddd tho, because im not sure if he will get the chance to see it. anyone who can, please help. im Methyl Trapped and i need to know if i only have b12 insufficiency, or b12 AND folate insufficiency. im sure i have b12 insufficiency. is this reason to believe i have Folate insufficiency/deficiency??? - IBS within twenty minutes of ingesting Metafolin. Cheilitis the next day - (i never supplemented with an active form of Folate before the one time it gave me the above symptom. ive only taken Folate 3 times,and it was Metafolin) - lack of B12 kicks MTHF out of cells and also there are no folate reserves. i now know that i have insufficient b12, because i have a total lack of THF to break down histamine. without sufficient b12 a METHYL TRAP occurs, where MTHF does not lose one of its methyl groups to become THF again. - this is whats happening to me. i need to know if i also have a folate deficiency/insufficiency. if i have a folate deficiency/, then i will supplement with Metafolin so that i get MTHF into the cell with b12 and i can get THF out of it,,,if i dont have folate deficiency/, then supplementing with Folate will only add onto the load of Folate that the B12 i ingest will have to turn into THF. really need help here. my histamine is still so high that its 100% debilitating. any excitement causes a rush of histamine - hotness,redness,itchyness .