I started Fred's protocol on May 26 and immediately started feeling better and sleeping better. I have had horrible sleep for the last 8 months and bad sleep for the last 5 years, but it got worse since July 2011 after my doctor pushed by dose of T3 too high and it started some kind of a storm in my body. I have been taking b-complex with methafolin 2 x day One in am one at lunch I take 3000g vit c in am and at noon A -am E-am DIM am and noon magnesium glycinate morn, and spread out throught the day Metafolate - varies. I might take an extra 1-3 a day besides what I get from my multi Potassium 1500-3000 just started 5mg DHEA today ( I have checked my level and I have low estrogen and Test) 4:1 oil 4-5 ---5000mg mb12 last one by around 1:00pm 1 - adb b12 am --tried 2 days not having any and I could hardly move I was so tired and depressed 1 ET b12 am 15mg zinc. (I am thinking of trying it in the pm based on what I have read.. interesting article here: http://www.nutritionexpress.com/article index/vitamins supplements a-z/showarticle.aspx?id=62 Lipase at meals 1 unisom at night. I haven't taken calcium yet. I seem to have issues with it. I just never feel right, but I have some cal/mag butryate and might start that. (short chain fatty acid) I started 1 drop of jarrow L-carnitine yesterday and 3 today. I have good energy today, but might be the adb as that give me energy. So when I first started the protocol. The viitamins were really putting me to sleep. Should I start adding in more supplements to keep things working? Any suggestioins? I don't fully understand the methylationi process. I have just ordered a 23 and me test. That will take about 4 weeks for me to have my results.