Hi Fred, Thanks for posting up your revised protocol. Unfortunately, I still have a few questions as I am very new to all of this. I have worked my way up to ¼ tablet of dibencozide, 1 tablet ET mb12 (1mg), 1 Jarrow mb12 (1mg) and 1600 mcg metafolin. I take all the basic supplements as well as 900 mg potassium per day (+ any episodic doses of 500 mg required). I am in the process of increasing my potassium. I would say I have had some mild ‘start up’ effects (light-headedness, a few tingling feelings and a slight increase in existing muscle spasms) and I have managed to get some of them under control with episodic doses of potassium. I wasn’t sure if I was doing the right thing but today I increased my metafolin to 1600 mcg. After the second dose of 800 mcg, my existing headaches and brain fog intensified and my mood deteriorated rapidly. I quickly took 500 mg potassium in case it was caused by an increase in my need for potassium but that doesn’t seem to have done very much. Do you think I increased my metafolin too quickly and should I return to my previous dose of 800 mcg? Or is this potentially a side effect of healing starting up that should improve in time? I am not sure whether to react to this or just ride it out. Now that I am taking 1 ET mb12 (1mg), 1 Jarrow mb12 (1mg) and ¼ tablet dibencozide, do I hold my mb12/adb12 dosage for a while and work on the metafolin/potassium balance or do I continue to steadily increase my mb12 & metafolin? OR, is now the time to add in L-carnitine? I am a bit unsure of what to do with the mb12 and metafolin at this stage & when to start adding in a co-factor like L-carnitine. Many thanks for any help anyone can give me!