I’ve got a question for the more experienced PWME. The initiatives that have popped up the last couple of years (rituximab, Lipkin, Davis and others) make me quite optimistic about the future. Hope that in the next 5 years big leaps forward in terms of knowledge about the pathology or maybe even in treatment are possible. Is that hope justified or a mere naive look towards the future from someone who is desperate to get better? I got my diagnosis at the end of 2011. This was at the same time the whole XMRV episode ended so I don’t have much knowledge how that was perceived in the community at that time (2009-2010). Have there been other big initiatives in the past that created a flare of hope but ended up being a bust (like XMRV) or didn’t fulfill the expectations for some reason (Ampligen?)? Or are the ongoing biomedical research and those that (hopefully) will be conducted in the nearish future on a scale that hasn’t been seen before in ME? Greetings from an ignorant fellow patient!