For those who can not bear living OverMethylated. I can suggest you consider low dose Stelazine with it. I am giving it up and I am never feel overmethylated when using it, but feel fine, like some sort of mania from B's. I guess I can handle it would have no problems. But for those who can not bear, Stelazine calms anxiety, mania, jitteriness etc. That would be another solution for you.