I am desperate for some guidance here. I live in the Middle East and am unable to find anyone to guide us. I know this is not a CFS question but please it is a methylation question.My nephew is 7 years old? He has a twin sister also. Last two years growth has been very slow and now his sister is a lot taller and bigger all round. Been slow in school and teachers saying his hands are weak. Seems he has no strength there at all. Was taken to the UK in the summer 2012 to Great Ormond Street Hopsital, and was diagnosed with gluten sensitivity. Has been started on stomach medicine to heal any damage done by wheat etc. Now 2 months on the medicine and off wheat totally. No change in growth and weakness continues. Have been following the forums here and another site for the last 2 years, I also have B12 issues and this site has helped me greatly. 2 weeks ago we started him on b complex without folic acid, for children and a methyl b12 liquid brand. Dose is 500mcg daily in the mouth. Also some children's acidophilus as was on antibiotics for months as they claimed he had heliobacter. Today, after 2 weeks his mother reports the boy is experiencing leg pains. I see this as being positive but to be honest I am totally lost I know to leave this situation is dangerous for the boy. I just wished we could have some guidance that we could rely on. There is no doctor here that is up on this subject. I have asked and all they give is cobalamin if there is deficiency. Would really appreciate any reply as I have trawler the Internet and no real support for this in children.