I took 5 methylfolate and folinic acid for several days. I had boundless energy. I basically felt completely cured of CFS. Come say day 4 now absolutely nothing. I might get a quick 5 minute rush after taking them but nothing. I was reading somewhere that taking high doses of folinic acid will make folinic (or 5methyl folate) plug into a part of the methylation cycle? In any event my fatigue block is definitely in this cycle. The folinic and methyl folate no longer do anything for me, even after adding in more methyl b12 and whatnot. What the hell happened?