Hi JPV, It hasn't. I've been at this for 8 years. Metafolin has only been available OTC for about 3-4 years and in a very limited fashion for 2 of those years. Source Naturals put out one batch and I bought a couple of dozen bottles in closeout. Than no more until it became available again about 2 years ago from other brands. So what has changed is because it is now possible to make a meaningful assessment of folic/folinic acid as compared to Metafolin and even work out a strategy. People who equate the paradoxical folate deficiency triggered by folic/folinic acid with the genuine effectiveness of Metafolin are making a mistake which becomes apparent if they continue the Metafolin. Also, I have been a systems analyst and software designer in health care since 1982. I designed all sorts of data input forms and questionnaires, and work-flow forms. I think that a single poll incorporating both protocols/variations and time stamped, so people can put in a change in results and watch how it changes over the months or years would be more useful for data collection that yields meaningful results. There are questions that can elicit meaningful responses and those that elicit responses that are less meaningful because they are based on false assumptions and/or have ambiguous answers. A question like "Do you have 'detox'?" is much less than meaningful and even misleading. It's like the traditional "When did you start beating your wife?" The things I have seen labeled "detox" that are not actually detox. Glutathione "detox" reaction - induced more severe methylfolate and b12 deficiencies. NAC "detox reaction" - induced more severe methylfolate and b12 deficiencies. "detox" when folic acid is being taken - paradoxical folate deficiency, induced more severe methylfolate and b12 deficiencies. "detox" when folinic acid is being taken - paradoxical folate deficiency, induced more severe methylfolate and b12 deficiencies. "detox" with mb12/mfolate when certain symptoms occur such as muscle spasms, heart palpitations and mood changes which often are falling potassium levels, hypokalemia. This is genuinely potentially dangerous and needs to be recognized, not called by the wrong name and treated incorrectly. When people are taking mb12/adb12/Metafolin and report "detox" for exactly the same reactions that many people have routinely reported as "startup" response leads to "danger" response rather than a "this will pass soon with healing" response. While some of the perhaps hundreds of startup responses might actually be because of some kind of "detox" the bulk of them are not. The difficult thing about all this is that each individual symptom is non-specific yet selected patterns are quite specific. And as mb12/mfolate are likely to induce multiple deficiencies if everything needed isn't taken I suspect much more is from these induced deficiencies than anything else. So like on the old TV program To Tell The Truth, "Will the real DETOX symptoms please stand up?" Let's see if we can identify them and eliminate all other possibilities. I think it likely that they do exist but finding them amongst all the misnomers is difficult. With all the male bovine manure around there is bound to be some bull somewhere. This "bad questions get bad answers" or in a more modern statement of it "Garbage In Garbage Out" (GIGO) plagues the research done in nutrition and medicine and probably much else.