Think I need to back down a bit... I've been taking a quarter of a 5,000mcg Jarrow b-12 for a few days, and today was HELLISH, -- just extreeeemely TENSE from about 11am till 9pm -- and that was with 1.5mgs clonazepam taken in 2 parts, starting at 2pm -- so I think I'm going to have to follow your lead and go down to 250mcg for awhile. If you started at 250mcg, how long was it before you upped the dose? And then did you increase it every week or so, or...? Hmmm...so perhaps you answered my earlier question: You took 250mcg for the first few doses...then added the mag chloride and the negative reactions went away? I've been taking 1/2 mag chloride tabs 3x a day -- not very much elemental mag -- but at least it doesn't give me the you know whats. I also took my first b6 (in p5p form) this afternoon, but was very tensed up before that, so don't think my bad day was a result of the b6. With dinner I had more mag, with my first ester C. Still not sure how "C" fits into methylation, but I'm sure I'll learn. Thanks everyone. Not sure how I'd get by without your help and your inspiring experiences w/improvement.