Shellbell -- I'm hope we're on to something too. When I took the other methylation supplements, I realized I wasn't taking these specific ones that Freddd or Kurt are taking, and was indeed taking "too much" folic and folinic acids. Which type or brand of folate are you taking? Both Kurt and Freddd suggest that Metafolin is the critical form. Also, I don't know if you noticed Kurt's comment, but he had kind of the same trouble with some of the other b vitamins -- but said the magnesium chloride made a big difference when it came to tolerating them. I think that's especially true for b6, which can be trouble for some with sulfation issues, but only if there isn't sufficient magnesium. Hopefully Kurt, Freddd or others with more smarts than I will comment too.