Hi Guys, I really battle with Methylfolate and any Methyl supplements (can tolerate them at all) - Probably because of my COMT V158M & H62H ++ mutations. I have tested positive for pyrroluria and will need to start supplementing something similar. I know folic acid is not great, but what about Folinic Acid? Would Follinic Acid still effect overmethylators/COMT folk? Pretty desperate as i think the higher levels of unbound copper are causing my anxiety/inner tensions - which has lead to my CFS after finding out about my COMT status and worrying myself into fatigue over the past 6months.