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Folate receptor (Folr1) functionality and antibodies

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Waverunner, Aug 23, 2011.

  1. Waverunner

    Waverunner Senior Member

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    Could it be that Folr1 functionality determines how well we react to folic acid in case of an already working methylation cycle? Moreover I heard that anti folate receptor auto-antibodies can keep folate out of the CNS. Is there a way to test for these auto-antibodies or does this only account for folic acid but not for folinic acid?

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860927/

    The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after injury. Here, we have shown in rodents that such repair occurs at least in part through DNA methylation. In animals with combined spinal cord and sciatic nerve injury, folate-mediated CNS axon regeneration was found to depend on injury-related induction of the high-affinity folate receptor 1 (Folr1). The activity of folate was dependent on its activation by the enzyme dihydrofolate reductase (Dhfr) and a functional methylation cycle. The effect of folate on the regeneration of afferent spinal neurons was biphasic and dose dependent and correlated closely over its dose range with global and gene-specific DNA methylation and with expression of both the folate receptor Folr1 and the de novo DNA methyltransferases. These data implicate an epigenetic mechanism in CNS repair. Folic acid and possibly other nontoxic dietary methyl donors may therefore be useful in clinical interventions to promote brain and spinal cord healing. If indeed the benefit of folate is mediated by epigenetic mechanisms that promote endogenous axonal regeneration, this provides possible avenues for new pharmacologic approaches to treating CNS injuries.
     
  2. determined

    determined Senior Member

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    USA: Deep South
    Thanks for posting this waverunner! I'm always looking for articles on this topic.
     
  3. aprilk1869

    aprilk1869 Senior Member

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    Scotland, UK
    You'll want to read Jeff's post at Better Medicine (formerly Wrong Diagnosis)

    http://forums.bettermedicine.com/sh...is-commonly-misdiagnosed.?p=298013#post298013

     
  4. Waverunner

    Waverunner Senior Member

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    Thanks so much for posting this AprilK. Deplin seems to be a great development but my overall goal for now is to stay away from milk because soluble milk folate receptor seems to cross-react with human FR.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715943/

    "One likely mechanism for autoantibody production could be that exposure to soluble FR from milk elicits an immune response."
     

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