Hi Robin, No, I don't. I think that as proper functioning of the body is restored the body will start handling these things in an orderly fashion. When a person starts mb12 and metafolin (other combinations may also work but this is most predictable with methylation starting almost immediately) the first thing induced in almost 100% will be low potassium. However, starting potentially 5 minutes after neurological changes can start as the nervous systfem starts working more and in 10 minuted ATP generation rises. These are effects that are signposts to healing, not something to get rid of. Calling low potassium "detox" is dangerous as it won't be treated correctly. The next most probable thing called "detox" is either induced folate deficiency or paradoxical folate deficiency, percentage unknown but probably in excess of 20%. Both can happen at same time or in sequence. Following those are any of a dozen or more induced deficiencies and possibly even an induced SubAcute Combined Degeneration. After all these are worked through generally healoing is going on at a good clip.