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Folate and DNA Methylation: A Mechanistic Link between Folate Deficiency and Colorect

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Freddd, Jan 25, 2012.

  1. Freddd

    Freddd Senior Member

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    http://cebp.aacrjournals.org/content/13/4/511.full

    From abstract:
    Epidemiological, clinical, and animal studies collectively indicate that dietary folate intake and blood folate levels are inversely associated with colorectal cancer risk. Folate plays an essential role in one-carbon transfer involving remethylation of homocysteine to methionine, which is a precursor of S-adenosylmethionine, the primary methyl group donor for most biological methylations. DNA methylation is an important epigenetic determinant in gene expression, maintenance of DNA integrity and stability, chromosomal modifications, and development of mutations. Dysregulation and aberrant patterns of DNA methylation are generally considered to be mechanistically involved in colorectal carcinogenesis. Aberrant DNA methylation has been considered as a leading mechanism by which folate deficiency enhances colorectal carcinogenesis.
     

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