The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
Discuss the article on the Forums.

FolaPro and various folate potency?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by sregan, Sep 9, 2014.

  1. sregan

    sregan Senior Member

    Messages:
    675
    Likes:
    380
    Southeast
    I'm just about to finish my bottle of Folapro and have finally run out of my "glass bottle" of Jarrow MB12.

    I can say that on my latest run of SMP I did NOT have the "brightening" I had the other times where I felt super good for at least a few days. Today I actualy felt very wired and agitated. I decided to take 200 mcg of Jarrow MethylFolate (QuatraFolic) with some Enzymatic MB12 and felt much better immediately.

    I also have a bottle (unopened) of Solgr Metafolin at the house.

    So my question is of the various forms why would the L-5-MTHF perhaps not be as effective for me as the (6S)-5-methyltetrahydrofolic acid (Jarrow) and possibly L-methylfolate-Metafolin (Solgar).

    http://mthfr.net/l-methylfolate-methylfolate-5-mthf/2012/04/05/
    seems to think the %L_MTHF == the 6S_L_MTHF

    Maybe the potency of my Folapro is questionable. Is it possible my body wants the (6S)-5-methyltetrahydrofolic acid preferably?
     
    Last edited: Sep 11, 2014
  2. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    According to this page:
    http://methy-life-site-testing.weebly.com/methylfolate-types.html

    it seems that Metafolin is 40% more potent than Quatrefolic. See the table where it indicates that 1mg Metafolin equals 1.4mg Quatrefolic. The reason is the absorption rate which is higher in Metafolin (~76%) vs Quatrefolic (~56%).

    From a subjective point of view I've tried both forms and didn't find particular differences. I also tried sublingual Quatrefolic (SeekingHealth) and did not do well on it, feeling super anxious and wired. I suspect it gets in the system too quickly and overstimulates my nervous system. Even at 800-1000mcg is too much for me. On the other hand I can tolerate 2000mcg of Metafolin without problems.

    cheers
     
    ahmo and Critterina like this.
  3. adreno

    adreno PR activist

    Messages:
    4,843
    Likes:
    11,022
    Subjectively I feel quatrefolic is more potent, it certainly feels more stimulating than metafolin.
     
    Critterina likes this.
  4. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    Out of curiosity do you take it orally or sublingually?
    I didn't find any differences with oral administration but definitely the sublingual Quatrefolic was highly stimulating for me, way too much.
     
  5. adreno

    adreno PR activist

    Messages:
    4,843
    Likes:
    11,022
    I take it orally.
     
  6. Critterina

    Critterina Senior Member

    Messages:
    1,202
    Likes:
    700
    Arizona, USA
    This is timely! Thanks @adreno and @PeterPositive !
    I just switched my Solgar for Piping Rock, both Metafolin, and have been feeling a lack of affect, wondering if it was due to the brands. Maybe I'll go back to Solgar first, then try Quatrefolic. So many excursions!
     

See more popular forum discussions.

Share This Page