With all these breakthroughs recently related to the Citric Acid cycle etc, there must be a way to flip the switch back. I don't know about anyone else but i'm pretty desperate and will try anything because living this way just isn't worth it. The reason I talk about flipping the switch is because i've experienced it myself, a few times in the past before I knew what M.E (International criteria) was I had 3-4 episodes where it felt like all the energy from every cell in my body had been removed in the space of 60 seconds, (often but not always during exertion) only to return and spontaneously recover after 30-45 minutes or so of rest/eating carbs and not happening again for months. Whatever has been shut down must be able to be turned back on surely. I know this is the question that everyone is trying to answer but we're getting close and I can't help but think the answer could be right beneath our noses. What is it that Staphypan/Rituximab for example have in common that helped people? I'm not too technical myself but I know there are people on this forum who can help us get closer to the answer. P.S I'm not interested in people pointing out the obvious like 'that's what the scientists are doing, leave it to them' I know that, but even waiting 3-5 years for a cure seems incredibly hard right now.