Hello everyone, I am going to get straight to the point. I think Leaky Gut is a very hard problem to overcome. I have tried the following solutions: Proline 500 mg Lysine 500 mg Glycine 500 mg Threonine 1000 mg Serine 500 mg Cysteine 500 mg Glutamine 1000 mg Colostrum 1000 mg Immunopro (1 scoop) This powerful cocktail gave me some results, but not enough in my opinion. What gave me really terrific results was Mucin (or Sialic Acid). When I took this supplement, I could feel that my gut was protected. I could feel heat emitting from my gut. I felt stronger physically. This heat is something I used to feel before I got sick. I read somewhere that Mucin Acid not only protects the gut, but it modulates the immune system. One of the reasons why we have ME/CFS is because our immune system is overactive. The one drawback from Mucin was the fact that it constipated me badly because it adds a thick coating to the intestines making the colon even smaller. I tried to take a smaller dosage of Mucin, and it somewhat worked. Like you want to take enough to coat your entire intestines completely, but if you mess up you will have to take supplements that dissolve mucus and start again. So, it is a lot of trial and error. Another problem is that I wonder if Mucin interferes with nutrient absorption. To get around the constipation issue, I want to try and take 500 mg of Apple Pectin with each meal, but I am tired of experimenting at this moment, maybe one of you guys can try it. Hopefully, the fiber will cause the colon to expand and will help the colon spacing to go back to its normal size with the thicken walls in place. I tried to look for a way to stimulate Mucin production in the body, but I couldn't find anything. Maybe one of guys could? I did find this for starters... https://en.wikipedia.org/wiki/N-Acetylmannosamine Maybe one of you geniuses could find out more. We are one step closer guys, I can tell.