Well, yes, I did have acid reflux, but no longer have it since I started on the Betaine, though I can't say that's the only reason, and it almost certainly isn't the only reason. To be honest I didn't have a lot of reflux exactly, unless I ate certain foods, but as Dr Myhill felt that I had hypochlorhydria I went with that along with the other things I changed. Having read Dr M and others on this acid issue, standard medical practice IS to treat with alkali (well they treat often with PPIs - and I assume they are alkali?), but my understanding is that the SYMPTOMS for low acid and high acid are the same (ie acid reflux). I always treated it cautiously as I knew I had a tendency towards gastritis and I certainly didn't want to worsen that, but in the end it seemed to work. I have tried stopping it in the past to test whether all was well now, and at the time it wasn't, but it might be worth me easing off it a bit now, and hope that my own acid production is up to scratch again. And yes, if you are vegan, maybe you wouldn't have such problems, as I believe that more acid is needed for higher protein meals.