In terms of adequately explaining all the wanton suffering and misery that exists in this world, the religious views of Gnosticism I find appealing sometimes. Gnosticism holds that the physical material world came into being by a cosmic mistake, along with its creator and ruler, the demiurge. In Gnosticism, the demiurge, not God, is responsible for designing and maintaining the physical world. The demiurge thinks himself a god, but he is only an emanation arising out of the true God. The material world created by the demiurge is inherently debased and imperfect, in contrast to the perfect, non-material and spiritual world that God inhabits. So even to begin with, humans live in a debased reality. But because humans have a divine spark within them, they are able to direct their attention away from this flawed physical world, and focus on that divine spark, the soul within, that links humans to God and the higher spiritual world. In this way, humans can to a degree escape the material world. However, the demiurge tries to counter this by filling human lives with material problems to create a distraction from our divine spark. That's the Gnostic view in a nutshell. In the Gnostic view, since we are living in an debased imperfect material world, one might fully expect suffering, disease and other miseries to be a part of this reality. In Gnosticism, this misery is not God's doing, but a result of living in an imperfect world created by the demiurge.