Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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First Direct Evidence of Neuroinflammation - 'Encephalitis' - in ME/CFS

Discussion in 'Phoenix Rising Articles' started by Phoenix Rising Team, Apr 28, 2014.

  1. SDSue

    SDSue Southeast

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    @Aerose91 How silly of me to get a wee bit hopeful. After all, you did say "psychiatrist". :lol:
     
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  2. osisposis

    osisposis Senior Member

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    Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):597-600.
    Impact of capsaicin on mast cell inflammation.
    Frydas S1, Varvara G, Murmura G, Saggini A, Caraffa A, Antinolfi P, Tete' S, Tripodi D, Conti F, Cianchetti E, Toniato E, Rosati M, Speranza L, Pantalone A, Saggini R, Di Tommaso LM, Theoharides TC, Conti P, Pandolfi F.
    Author information
    Abstract

    http://www.ncbi.nlm.nih.gov/pubmed/24067456
     
  3. osisposis

    osisposis Senior Member

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  4. Leopardtail

    Leopardtail Senior Member

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    Half true?

    Simon, do you mean sickness behaviour as in promoting rest, or sickness behaviour as in immune response here?

    The fever response (according to my understanding) tends to kick in after several days of infection and failure of the immune system to deal with the problem. As you indicate microbes are more temperature sensitive than our cells and the immune response uses fever to weaken them. It is because it may indicate a more severe infection that medics are concerned by it.

    The info re reptilian response to infection was in interesting tit bit, may I ask where you picked that up?

    Leo
     
  5. Leopardtail

    Leopardtail Senior Member

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    More importantly how this compares with depression in order to put the psychiatric dogma to sleep permanently..
     
  6. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    My own understanding is that fever is actually one of the early responses to infection - part of the innate immune system.

    This page appears to support this, e.g. this bit:

     
  7. Leopardtail

    Leopardtail Senior Member

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    The page is slightly misleading (re fever at least). In so far as we are born with innate immunity it obviously comes first in two respects. Aspects of it also kick in a little quicker than the th1 system. What's described as innate immunity includes most b-cell activity, natural killer cells etc as well as fever.
    Fever actually commences after NK cells, T-cells etc and is primarily an endocrine response to infection. We don't fever ever time we get a cold due to it being the bodies 'emergency response'.

    It was the length of time about which I had my doubts.
     
    Last edited: Jun 30, 2014
  8. osisposis

    osisposis Senior Member

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  9. Aerose91

    Aerose91 Senior Member

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    "Learned responses" that's a great way to put it. I have been saying I operate solely on logic. I would feel horrible for a child that has to go through this because they haven't had a chance to learn the correct behaviors and responses to things.

    I never get periods of OK brain function though. Never fluctuates, ever, not even 1%
     
  10. alex3619

    alex3619 Senior Member

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    By OK brain capacity I mean times when I can think at 30% or more of normal capacity, rather than times when I am at 1%.
     
  11. helperofearth123

    helperofearth123 Senior Member

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    Fantastic beaverfury, I'm glad to hear you're improving. :)
     
  12. funkyqueen

    funkyqueen Senior Member

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    Nobody know if this study will be replicated ??
     
  13. *GG*

    *GG* Moderator

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    Is the article available as a PDF?
     
  14. Hasz

    Hasz

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    This is a study that describes how I felt at worst and during every relapse. My most recent one pretty bad and I described it to a doctor saying: it feels upon waking up as if my brain was full of some sort of yellow pus which has to get out but wont. It makes my head soinning at first and then impacts the most basic funtions from sleeping, eating and peeing to standing speaking, holding anything in my hands. It is all tragic that makes me laugh at times how bad can it be this time? I seem to develop more and more symptoms with most recent addition tightness round my throat and problems swallowing as well as getting food into my stomach it all seem to go up involuntary (yes some muscles freak up and soasm while some other seem to stop working). Basically my brain seems to be so inflammed that it stop to function and so my body shuts down. All due to another silly docile virus my kid brought home. Any help for temporary flare ups in brain inflammation? Which btw was not recognised by basic blood tests CRP was very low but I had low grade fever. Merry Xmas everyone.
     

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