Two weeks now on the @Freddd protocol, with some nice changes. Any comments will be welcome: Pre-protocol: Bad brainfog, fatigue, low mood, 10+ hours sleep a day. Aug 27: Began the general support supps (various Bs, lecithin, taurine, E, etc). The short-term effect was euphoria. The lasting effect has been that the brainfog of recent months evaporated on Day 1 & hasn't returned. 'Jaggedness' & 'stressedness' of recent weeks is gone. No longer obsessive, irritable & pissed off. Was able to drop my dose of hydrocortisone from 20mg to 15. Aug 29: Began the actual protocol with Metafolin 200mg x 4 times a day. Aug 30: Began m-B12 x 1mg sublingual/day. A few waves of tiredness & nausea. Felt a bit 'pummeled'. Aug 31: A bit of anxiety on waking. m-B12 tab doubled to twice a day. 2 hour period of tiredness in afternoon. Sep 1: A bit of nausea, so took some potassium. It passed. Sep 2: Woke bright as a button on 6 hours sleep. Haven't done that for a long time. Increased the folate to 400mcg/4 times/day. Sep 4. Still on 8 hours sleep, down from 10+ hours pre-protocol. Took 2mg Adb Cbl - made me a little groggy. Sep 5. Took the AdbCbl on an m-B12-free day this time: total of 8mg through the day (all sublingual). Sep 6: Waking temp 36.3, so that hasn't changed with the protocol. Had a 'whacked' feeling, tho it was paradoxical: as if my body was sending a message to my brain that I was tired: but in fact I could work just fine. Never had this feeling before. Yesterday's AdbCbl? Sep 8: Began 1 capsule of acetyl l fumerate 855mg daily. No effects yet. The big changes are that the support supps removed my brainfog, & the mB12 and m-folate removed my fatigue. The AdbCbl seemed to lift the fatigue a little more. Questions: I didn't have any significant start-up symptoms. Any comments? Should I be titrating up, or is everything fine? (Now m-B12 1mg x twice a day; Metafolin 400mcg 4 times/day; AdbCbl 8mg once a week; Fumerate 1 cap daily.) I have had a great improvement in energy, & the brainfog is gone. Should I be shooting for something else? (I have psychological symptoms of long-standing - e.g. tendencies to obssession, depression, anxiety, tho they don't loom too large any more thanks to therapy & time. And psoriasis for 40 years.) Thanks to all.