The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
Discuss the article on the Forums.

Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in

Discussion in 'Latest ME/CFS Research' started by Bob, Apr 25, 2015.

  1. Bob

    Bob

    Messages:
    9,846
    Likes:
    33,923
    England (south coast)
    Not open access, unfortunately.

    A large multi-center study by Klimas, Bateman, Levine, Peterson, Hornig, Komaroff and colleagues.

    "This paper introduces the Chronic Fatigue Initiative..."

    Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome

    N.G. Klimas, G. Ironson, A. Carter, E. Balbin, L. Bateman, D. Felsenstein, S. Levine, D. Peterson, K. Chiu, A. Allen, K. Cunningham, C.G. Gottschalk, M. Fletcher, M. Hornig, C. Canning & A.L. Komaroff
    Fatigue: Biomedicine, Health & Behavior 2015; 3:75-96
    Published online: 24 Apr 2015
    DOI:10.1080/21641846.2015.1023652
    http://www.tandfonline.com/doi/abs/10.1080/21641846.2015.1023652

     
    Last edited: Apr 25, 2015
    Comet, Dolphin, MEMum and 20 others like this.
  2. Sasha

    Sasha Fine, thank you

    Messages:
    12,756
    Likes:
    33,927
    UK
    Pity it's not open access - I'd like to know more about the subgrouping.

    I like the conclusion! :thumbsup:
     
    Kati, leela, sarah darwins and 4 others like this.
  3. Bob

    Bob

    Messages:
    9,846
    Likes:
    33,923
    England (south coast)
    Looks like it could be quite a significant paper. I'd like to read this one.
     
  4. aimossy

    aimossy Senior Member

    Messages:
    1,071
    Likes:
    3,657
    It is probably the exact sort of paper Doctors need to be reading @Bob. I would like get/see this one too.
     
    leela, sarah darwins, Bob and 2 others like this.
  5. jimells

    jimells Senior Member

    Messages:
    1,996
    Likes:
    6,075
    northern Maine
    Now tell me something we didn't already know 30 years ago...
     
    cigana, beaker, oceiv and 5 others like this.
  6. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
    Edited to add:
    DSQ = DePaul Symptom Questionnaire

    CFI = the Chronic Fatigue Initiative

    The CFI symptom checklist = 'a general review of 50 symptoms for all potential cases and [Healthy Control]s to explore general health as well as potential clusters of symptoms relevant to ME/CFS. [...] For each symptom, the question asked of the prospective case or control was, “Over the past 6 months have you had [this symptom] frequently or constantly?” Each symptom was then noted by the interviewer as present or absent.'

    (@Sasha)
     
    Last edited: Apr 26, 2015
    Sasha, oceiv, SOC and 2 others like this.
  7. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
    more about the subgrouping:

     
    Dolphin, Sasha, oceiv and 4 others like this.
  8. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
    [​IMG]
    (I'm not sure how much one is allowed to share wrt copyright etc... please let me know if I've exceeded the limit!)
     
    Dolphin, Sasha, oceiv and 3 others like this.
  9. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
  10. aimossy

    aimossy Senior Member

    Messages:
    1,071
    Likes:
    3,657
    :)
     
    oceiv and mango like this.
  11. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
     
    Dolphin, Sasha and aimossy like this.
  12. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
    I found this a bit "interesting":
     
    Dolphin, MEMum, Sasha and 6 others like this.
  13. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
     
    Dolphin, Sasha, oceiv and 4 others like this.
  14. alex3619

    alex3619 Senior Member

    Messages:
    12,251
    Likes:
    33,572
    Logan, Queensland, Australia
    For text its 10%. Not sure about tables. (Or it used to be, I haven't looked into this in many years.)
     
    merylg, mango and aimossy like this.
  15. jimells

    jimells Senior Member

    Messages:
    1,996
    Likes:
    6,075
    northern Maine
    Keep digging! There's gotta be a pony under all that data! :D
     
  16. mango

    mango Senior Member

    Messages:
    895
    Likes:
    4,858
    unfortunately i don't have a trained eye for this sort of thing, i'm sure someone else could find and highlight other/better parts and details :) russell on twitter mentioned that he'll have a look at it, and perhaps @Bob has something to add?
     
  17. Dolphin

    Dolphin Senior Member

    Messages:
    10,552
    Likes:
    27,442
     
  18. Dolphin

    Dolphin Senior Member

    Messages:
    10,552
    Likes:
    27,442
    Klimas 1.png
    Klimas 2.png
     
    Valentijn and Sean like this.
  19. Dolphin

    Dolphin Senior Member

    Messages:
    10,552
    Likes:
    27,442
    Klimas 3.png
    Klimas 4.png
     
    Valentijn and Sean like this.
  20. lnester7

    lnester7 Seven

    Messages:
    2,270
    Likes:
    3,174
    USA
    I just want to make a comment, in Klimas group even thought they use CCC, they run A LOT of tests and they use it to diagnose also, is not just you are CCC, they account for NK activity, T cells, B cells and the whole immune profile...... So I trust the patient pool.

    We fill out the SF-36 every time you have a CFS consult (the in person one). So they track the progress over time. Is helpful for one self also.
     
    Comet likes this.

See more popular forum discussions.

Share This Page