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Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in

Discussion in 'Latest ME/CFS Research' started by Bob, Apr 25, 2015.

  1. Bob

    Bob

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    Not open access, unfortunately.

    A large multi-center study by Klimas, Bateman, Levine, Peterson, Hornig, Komaroff and colleagues.

    "This paper introduces the Chronic Fatigue Initiative..."

    Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome

    N.G. Klimas, G. Ironson, A. Carter, E. Balbin, L. Bateman, D. Felsenstein, S. Levine, D. Peterson, K. Chiu, A. Allen, K. Cunningham, C.G. Gottschalk, M. Fletcher, M. Hornig, C. Canning & A.L. Komaroff
    Fatigue: Biomedicine, Health & Behavior 2015; 3:75-96
    Published online: 24 Apr 2015
    DOI:10.1080/21641846.2015.1023652
    http://www.tandfonline.com/doi/abs/10.1080/21641846.2015.1023652

     
    Last edited: Apr 25, 2015
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  2. Sasha

    Sasha Fine, thank you

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    Pity it's not open access - I'd like to know more about the subgrouping.

    I like the conclusion! :thumbsup:
     
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  3. Bob

    Bob

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    Looks like it could be quite a significant paper. I'd like to read this one.
     
  4. aimossy

    aimossy Senior Member

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    It is probably the exact sort of paper Doctors need to be reading @Bob. I would like get/see this one too.
     
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  5. jimells

    jimells Senior Member

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    Now tell me something we didn't already know 30 years ago...
     
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  6. mango

    mango Senior Member

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    Edited to add:
    DSQ = DePaul Symptom Questionnaire

    CFI = the Chronic Fatigue Initiative

    The CFI symptom checklist = 'a general review of 50 symptoms for all potential cases and [Healthy Control]s to explore general health as well as potential clusters of symptoms relevant to ME/CFS. [...] For each symptom, the question asked of the prospective case or control was, “Over the past 6 months have you had [this symptom] frequently or constantly?” Each symptom was then noted by the interviewer as present or absent.'

    (@Sasha)
     
    Last edited: Apr 26, 2015
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  7. mango

    mango Senior Member

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    more about the subgrouping:

     
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  8. mango

    mango Senior Member

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    [​IMG]
    (I'm not sure how much one is allowed to share wrt copyright etc... please let me know if I've exceeded the limit!)
     
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  9. mango

    mango Senior Member

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  10. aimossy

    aimossy Senior Member

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    :)
     
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  11. mango

    mango Senior Member

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  12. mango

    mango Senior Member

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    I found this a bit "interesting":
     
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  13. mango

    mango Senior Member

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  14. alex3619

    alex3619 Senior Member

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    For text its 10%. Not sure about tables. (Or it used to be, I haven't looked into this in many years.)
     
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  15. jimells

    jimells Senior Member

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    Keep digging! There's gotta be a pony under all that data! :D
     
  16. mango

    mango Senior Member

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    unfortunately i don't have a trained eye for this sort of thing, i'm sure someone else could find and highlight other/better parts and details :) russell on twitter mentioned that he'll have a look at it, and perhaps @Bob has something to add?
     
  17. Dolphin

    Dolphin Senior Member

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  18. Dolphin

    Dolphin Senior Member

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    Klimas 1.png
    Klimas 2.png
     
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  19. Dolphin

    Dolphin Senior Member

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    Klimas 3.png
    Klimas 4.png
     
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  20. lnester7

    lnester7 Seven

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    I just want to make a comment, in Klimas group even thought they use CCC, they run A LOT of tests and they use it to diagnose also, is not just you are CCC, they account for NK activity, T cells, B cells and the whole immune profile...... So I trust the patient pool.

    We fill out the SF-36 every time you have a CFS consult (the in person one). So they track the progress over time. Is helpful for one self also.
     
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