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Finding and identifying deficiencies while on SMP (Methylation Protocol)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by sregan, Oct 5, 2017.

  1. Learner1

    Learner1 Professional Patient

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    You're exactly right!

    Methylation is involved in almost every bodily biochemical reaction, and occurs billions of times every second in our cells, managing or contributing to a wide range of crucial bodily functions, including:

    Detoxification
    Immune function
    Maintaining DNA
    Energy production
    Mood balancing
    Controlling inflammation

    Sound familiar? It helps our bodies respond to environmental stressors, to detoxify, and to adapt and rebuild. Lowered methylation function contributes to diseases, including:

    ME/CFS
    Cardiovascular Disease
    Cancer
    Diabetes
    Allergies, immune system, and digestive problems
    Neurological conditions
    Mood and psychiatric disorders
    Miscarriages, fertility, and problems in pregnancy
    Aging

    That’s why optimizing methylation contributes to health improvement, and reducing symptoms.
    Exactly. And not just super detox mode, super mode of helping allergies, immune function, neurological function, etc.

    If you speed up parts occur, you have to speed all of it in a balanced approach. You also need to get rid of the waste products and ensure things that need recycling, like glutathione, methionine, and homocysteine are getting recycled.

    We were fortunate to have an expert doctor fix my child's methylation over time. She returned to high level sports training and competition, and over a 2 year period, he ramped up her methylation to meet her body's increased demands during the sports season, then slowed it down when out of season. Watching that process taught me a lot about how the cofactors work together and how to manipulate methylation.
    Exactly. There are tools today where you can get a decent idea of how your methylation genes are likely to express themselves. We've used them and found the theories to work.

    But, environmental factors, like infections, diet, toxicity, etc. can impact how the genes express themselves. "Your mileage may vary."

    Testing periodically, like every 9-12 months, is wise. Every test has a theme and you can see where bottlenecks are occurring and how to unblock them and where the subsequent bottlenecks are likely to occur too head them off.

    My family tends to need huge amounts of B6 in the form of P5P - it shows up again and again. The genetics don't necessarily shout it out (or maybe we're not looking at the right genes) but B6 is used in methylation and hemoglobin and sphingolipid production. You can likely see why not having enough can contribute to ME/CFS.

    So, even though the "daily value" of B6 is about 1.5mg, and toxicity has been reported in some people at 200mg, my body seems to drink up 350mg a day and fall apart without that much. If I didn't test, I never would have learned about it. And deficiency shows up in bottlenecks all through the test.
    Balance is the key. You have to get the entire process, with all its cofactors, working from end to end. Once you have it under control, you can ramp it up or down to cope with stresses your body encounters.

    And, it has to be what works for you, your genes, your toxic load and other cell dangers.

    So many people try one or two nutrients, like folate or B12, and start to experience symptoms as they are doing too much to start, missing cofactors, or inadvertently mobilizing toxins they aren't ready to get rid of and just reabsorb.

    This is why people say it didn't work for them, they can't tolerate methylating supplements, and they quit. Its extremely unfortunate, as it is impossible to be well without having properly functioning methylation. And worse, it can lead to cancer and mental illness.

    Vexing, but worth figuring out.;)
     
    sregan and Mary like this.
  2. sregan

    sregan Senior Member

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    I'm doing somewhat better, I think I'm identifying deficiencies and correcting. Still up and down but better overall. One thing I hadn't considered is Folate deficiency. I've basically been staying away from it completely (unless in food) especially MFolate. But I probably need to supplement at least a minimum dosage? I'm almost scared of this at this point.
     
  3. sregan

    sregan Senior Member

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    Good link on common deficiencies while on the SMP: click here

     
  4. sregan

    sregan Senior Member

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    I've got a question about supplementing Iron. How does one do it? I've heard stories about feeding Candida and possible use of Lactoferrin?
     
  5. pamojja

    pamojja Senior Member

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    Tried different iron supplement without success. What finally brought my iron levels up was betain-hcl.
     
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  6. sregan

    sregan Senior Member

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    @pamojja I found a digestive enzyme I already have that has betaine in it. Do you take it by itself?
     
  7. sregan

    sregan Senior Member

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    So in the last couple of weeks I believe I have uncovered 3 deficiencies by trial and error taking one supplement at a time. They are Zinc, Iron and Lithium. I believe at one time I was deficient in Copper also.

    I tried a small amount of mfolate a couple of days ago and it made me feel worse. I don't expect i can take it again until I've discovered all the deficiencies. But once that's done I should be good.
     
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  8. pamojja

    pamojja Senior Member

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    Usually the recommendation for low stomach acid - other than testing it directly - is to take one betain-hcl tablets/cupsule and gradually increase till discomfort starts. Then take a decreased dose.

    In my case just one capsule moved my deficient iron markers (TIBC, TSAT, transferrin) in a better but still not normal place. Already 2 capsules raised serum iron too high. Heart some need grams of this stuff to have better nutrient absorptions. So it's a very individual thing.
     
    sregan likes this.
  9. sregan

    sregan Senior Member

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    Just dawned on me that betaine is TMG! (Betaine Anhydrous). Does anyone know if Betaine HCI acts as the TMG methylation shortcut also?

    From: http://www.raysahelian.com/betaine.html



     
    Last edited: Nov 22, 2017
  10. Dabam

    Dabam

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    I always test low for zinc and magnesium so slowly raising these.

    Just ordered B1,B2,B3 so will be adding these in small amounts back into my protocol was taking brewers yeast to cover all the bases but this stuff sent me up the wall.

    I have been looking into lithium but I am thinking I better steady the ship first
     
  11. sregan

    sregan Senior Member

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    I started with lithium.. Just one 5mg tablet at a time with Iodine. It seems to have a nice relaxing effect at first. I will feel really good but a little jittery late in the day with some anxiety. And seem to wake with some anxiety. The studies showed that lithium is supposed to increase sensitivity to cortisol If feels like it's lowering cortisol.
     
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  12. stridor

    stridor Senior Member

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    I have experienced shortage of B2, twice. For first 5 years could only seem to absorb folate sublingual. Worked 3 years to get my ferritin level from 9 to 50. Vit D is low without supplementation.
     
  13. Dabam

    Dabam

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    My anxiety is high at the moment so it's probably best to leave the lithium out for a while after reading your experience with it.
     
  14. sregan

    sregan Senior Member

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    It's hard for me to know what to think at the moment for Lithium. If it increases your sensitivity to cortisol then that should mean less cortisol is more. So it should help someone with low cortisol. But it "feels" like it's lowering cortisol although I don't have the increased inflammation from taking this (so far anyway)
     
    Last edited: Nov 30, 2017
    Dabam likes this.
  15. Dabam

    Dabam

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    I know the Mrs was taking lithium to help with the menopause she was doing fine for a few weeks then all hell broke loose,it sort of put me off it.
     
  16. sregan

    sregan Senior Member

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    Was she taking Iodine or thyroid support also?
     
  17. Dabam

    Dabam

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    To be honest she wasn't ,that could account for the severe crash she had
     
  18. sregan

    sregan Senior Member

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    I've found again I have a Potassium deficiency. I've told myself again and again if I take Methyl B12 I'll need to take potassium. Finally figured this out yesterday after weeks of suffering. Don't know how I missed it since it's probably the most likely deficiency in SMP land. (banging head against a wall). We'll anyway I'm learning that to address these most likely are the big 3 (Potassium, Magnesium and Zinc), leaving MB12 and MFolate out of the picture for now. I'm not taking any MFolate and just a smige of MB12 here and there. I needed 370mg of potassium today because I took 1/4th of an Enzymatic MB12.
    MB12 deficiency (Methyltrap) is horrible and I've experienced MFolate deficiency also and it feels very bad (in a brain chemistry type of way). Potassium not so much messes directly with your head as it just makes you feel awful. After weeks of it and not knowing what it might be you might think you have something really wrong with you and your days are numbered. I had the same experience with Zinc being low.
    I'm trying to get to a place where I can just stop taking everything for a while and feel decent. I'm encouraged that I might be getting there if I can cover my deficiencies. As much as SMP can possibly give you, it sure can take everything away if you don't know what you're doing.
     

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