It's taken nearly 3 months, but I've just received an email from 23andme to let me know that my results are ready. After running the data through Geneticgenie, this is what I've got: Methylation VDR Taq ++ MAO-A R297R ++ MTRR A66G ++ MTRR A664A ++ COMT V158M +- COMT H62H +- MTHFR C677T +- BHMT-08 +- CBS C699T +- Detox (all heterozygous) CYP1A2 164A>C CYP1B1 L432V CYP1B1 N453S CYP1B1 R48G CYP2C9*3 A1075C CYP2C19*17 CYP2D6 S486T CYP2D6 100C>T SOD2 A16V NAT2 I114T NAT2 K268R I've tried to look up all of these mutations and get some idea of what they do and how they might interact, but there doesn't seem to be much information out there for some of them. From my understanding the MTHFR and MTRR mutations mean that I need to supplement with methylcobalamin and methylfolate (which I've been doing for the last four months) but the COMT mutations mean that I'm sensitive to methyl donors (which has certainly been my experience) so I need to start with low doses and increase slowly and carefully. The CBS mutation complicates things further, as it means that my transsulfuration pathway gobbles up all the methyl donors and converts them to taurine and ammonia. I gather that there's some disagreement about the extent to which this mutation poses a problem, but my most recent test results showed that my ammonia levels were very high while my glutathione levels were very low, so it looks as if this is an issue for me. The VDR mutation will also have an effect on the CBS one, but I can't work out whether it'll be offsetting the impact or making it worse. Can anyone enlighten me? Looking at the Detox SNPs, the one that stands out to me is SOD2 as I know that my Mn-SOD level is very low (as is my Zn/Cu-SOD level). Does that seem like an accurate summary or have I overlooked something important in these results? I only starting to understand the basics of SNPs and mutations, so I'd be grateful for comments from anyone with a better grasp of the subject.