(Also posted to my blog) It took about 3 months but I'm finally feeling "my normal" again. I have been laying off all SMP sups and taking about 50 mg B3 per day. Each day I'm also taking my minerals with a small amount of B1, B2 and 7 mg p5p. I believe perhaps my methylation never stopped. I'm not sure how it could unless other systems in the body can make up for it somehow. I think the last ten years my methylation has been way below normal. Taking the SMP sups has given it a boost, perhaps my diet at times on certain days has also increased the turnover of this cycle. The days that I've felt wonderful I believe is an equilibrium point when my neurotransmitter production is given a boost by methylation. After that either a downregulation of the receptor sites happens or the other idea that once methylation gets boosted the liver becomes overloaded with toxins, the gut becomes rebellious, inflammation goes through the roof. Whatever the case. I thank Caledona for her post on Sep 10 about slowing down Methylation. I assumed I could just pop a little B3 and that would do it. Not in my case anyway. If I had the above info earlier I might have ended this episode in a few days instead of a couple of months. I'm grateful that I didn't permanently change something, for the worse, in my body by attempting SMP. I think that is the biggest worry for most of us is that we could actually make things worse when things are already worse.