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Fidelity of target site duplication and sequence preference during XMRV integration

Discussion in 'XMRV Research and Replication Studies' started by subtr4ct, Apr 28, 2010.

  1. gu3vara

    gu3vara Senior Member

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    Gerwyn : So I'm understanding that you are pretty confident XMRV could cause CFS based on this science paper? That's awesome news! :)

    I'm just wondering why my girlfriend didn't have CFS after 9 years together and me being sick for 5 years (at least), is it essential to have an already weakened immune system to let it take control of our bodies? (I had some vitiligo since childhood and hashimoto thyroiditis for a long time too and I'm wondering if autoimmune diseases are a consequence or rather the a determinant factor that leave the door open to XMRV).

    Would like to know your thoughts on that, thx!
  2. natasa778

    natasa778 Senior Member

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    jumping in here...

    simplest explanation imo could be that your girlfriend's genetic make-up is such that she is either not suceptible to xmrv infection at all (say through protective polymorphisms in membrane receptors, not allowing xmrv cell entry), or through some immune genes like APOBEC etc that efficiently deal with the infection so it does not take hold (so that she gets infected but xmrv is kept in check straight away).

    then more complicated versions of xmrv is there but has randomly inserted into genes that do not cause problems (or 'not YET), in marginal tissue/cells, and it is permanetly latent through good methylation etc etc. or even more complicated versions of her being positive but there would be a need for coninfections, oxidative stress, toxin exposure etc. for xmrv to start causing problems...
  3. gu3vara

    gu3vara Senior Member

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    thx Natasa, I sincerely hope that the simplest explanation rules here... I don't want to see her getting sick because of me
  4. alphahusky

    alphahusky

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    Personally, I think it goes dormant at times. No one I've been with or any family has ever gotten it, though I gave Mono to someone a full year after I had it.
  5. Gerwyn

    Gerwyn Guest

    polymorphism in XPR-1 receptor could be a factor.XMRV could cause illnesses not recognisable as ME high blood pressure tacycardia osteoporosis anciety etc gastric problems asthma the list is pretty long
  6. gu3vara

    gu3vara Senior Member

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    Wow, XMRV discovery could turn out to be the greatest things since bread came sliced...! Imagine if it was involved in some serious autoimmune disease like lupus or MS too.

    It now seems we are closer to the Nobel prize than the flop...thank god for that
  7. JillBohr

    JillBohr Senior Member

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    Thank you Gerwyn. Sorry it to long to thank you but when I read your response.....

    The excitement set off my autonomic nervous system. Which then became dysfunctional which left me with the neuroendocrine symptoms of ME sensitivity to lights, sound, high resting heartrate POTs poor temperature control and so on. As you know, the organic thermostat that controls all these functions is the hypothalamus and when any function such as heart rate strays outside the normal range this is detected by the hypothalamus and brought back into normal ranges by the action of the pituitaty gland and the Adrenal cortex (and medulla). So the control system broke down my autonomic functions and then went haywire.

    Oh..... I am so thankful to have you geeks here.
  8. Robyn

    Robyn *****

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  9. jewel

    jewel Senior Member

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    Amazing explanations, Gerwyn and Natasa. Thanks, J.
  10. citybug

    citybug Senior Member

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    When scientists read this study are they going to get the CREB and NFAT effects immediately or do you need to understand ME/CFS?
  11. citybug

    citybug Senior Member

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    Are there any treatment possibilities that address the receptors?

    Is this right-Those are the human cell receptors and cortisol, progesterone, testosterone and cytokines? for inflammation attach to the xmrv receptors?
  12. helsbells

    helsbells Senior Member

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    I too just want to thank the geniusus (geniai??) who take the time and trouble to break this down for brain addled, long time affecteds' like myself. It is beyond kind to take the trouble of sharing what you understand. I am struggling terrifically with MCS at the moment ( an unavoidable house move radiator paint, dust, perfume smell etc etc etc etc ) and actually coming and reading this stuff really lifts me from much darker thoughts. Thank you so much
  13. natasa778

    natasa778 Senior Member

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    No, not for the XPR1 receptors, as far as I'm aware. That one is the primary xmrv entry receptor. There may be others it uses in additon to xpr1 (currently being researched) for which there could be receptor blockers already out there.

    Sorry I don't understand the rest of your question.
  14. subtr4ct

    subtr4ct Senior Member

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    It seems to be new. I also saw it go by on the Google Alert yesterday. Seems to be just a review/survey piece. Interesting that it appears in an allergy focussed journal. May have some interesting speculation regarding the subtle immune effects seen in CFS that could be caused by XMRV. No time to read it at the moment... Seems like it probably deserves it's own thread, even if it's nothing earth-shattering.
  15. hvs

    hvs Senior Member

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    This might be right, or it might not be genetics but rather that it's
    1. actually quite hard to pass along, but given enough time and enough hanky-panky one probably will
    2. one's partner might have it but it's not manifesting as something that looks like XAND/"cfs" [I believe that Gerwyn stated something like this]
  16. Gerwyn

    Gerwyn Guest

    i think this is very tentative that they may be greater in number and or slightly different in structure in men and women
  17. V99

    V99 *****

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    This was posted on co cure http://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind1004E&L=co-cure&P=R307

    Have a look at the part in red where they discuss prostate cancer. Is this another study they are talking about? or the one already mentioned?

  18. Gerwyn

    Gerwyn Guest

    hohn produced the other negative study .In fact This appears to be the same one!

    589 prostate tumor samples were genotyped by real-time PCR with regard to the RNaseL mutation. DNA and RNA samples from these patients were screened for the presence of XMRV-specific gag sequences using a highly sensitive nested PCR and RT-PCR approach. Furthermore, 146 sera samples from prostate tumor patients were tested for XMRV Gag and Env antibodies using a newly developed ELISA assay. In agreement with earlier data, 12.9% (76 samples) were shown to be of the QQ genotype. However, XMRV specific sequences were detected at neither the DNA nor the RNA level. Consistent with this result, none of the sera analyzed from prostate cancer patients contained XMRV-specific antibodies.

    Our results indicate a much lower prevalence (or even complete absence) of XMRV in prostate tumor patients in Germany. One possible reason for this could be a geographically restricted incidence of XMRV infections.
    Background

    compared with

    Results: 589 prostate tumor samples were genotyped by real-time PCR
    with regard to the RNaseL mutation. In agreement with earlier data,
    12.9% (76 samples) were shown to be of the QQ genotype. However, XMRV
    specific sequences were detected at neither the DNA nor the RNA level
    and none of the 146 sera analyzed from prostate cancer patients
    contained XMRV-specific antibodies. The outcome of the ongoing CFS
    study will be presented at the conference.

    Conclusion: Our results indicate a much lower prevalence (or even
    complete absence) of XMRV in prostate tumor samples in Germany. One
    possible reason for this could be a relatively recent acquisition of
    the virus from a murine host and a geographically restricted incidence
    of XMRV infections.

    ------------------------------------- THIS IS NOT A NEW STUDY BUT THEY ARE BOLTING ON CFS TO A STUDY THAT WAS NOT DESIGNED TO INVESTIGATE ME AT ALL!

    ANYONE KNOW WHEN THIS IS GOING TO BE PRESENTED ESPECIALLY IN RELATION TO DR JUDY,s WORK
  19. V99

    V99 *****

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    Sorry Gerwyn I meant the CFS study they mention. Are they saying more info is coming on CFS XMRV?
  20. Gerwyn

    Gerwyn Guest

    the prostate cancer part of the"study" is identical to their study already published.They have merely added the cfs bit retrospectively

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