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Fibromyalgia Research: Potential blood test for fibromyalgia

Discussion in 'Fibromyalgia' started by Bob, Jul 24, 2013.

  1. Bob

    Bob

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    It seems that this paper has been available since April, but I haven't seen it before, and I can't see it posted on the forum.


    A bloodspot-based diagnostic test for fibromyalgia syndrome and related disorders
    Kevin V. Hackshaw, Luis Rodriguez-Saona, Marçal Plans, Lauren N. Bell and C. A. Tony Buffington
    Analyst, 2013,138, 4453-4462
    DOI: 10.1039/C3AN36615D
    Received 05 Nov 2012, Accepted 03 Apr 2013
    First published online 4 Apr 2013
    http://pubs.rsc.org/en/content/articlelanding/2013/an/c3an36615d

    Abstract:
    The aim of this study was to investigate the ability of a rapid biomarker-based method for diagnosis of fibromyalgia syndrome (FM) using mid-infrared microspectroscopy (IRMS) to differentiate patients with FM from those with osteoarthritis (OA) and rheumatoid arthritis (RA), and to identify molecular species associated with the spectral patterns. Under IRB approval, blood samples were collected from patients diagnosed with FM (n = 14), RA (n = 15), or OA (n = 12). Samples were prepared, placed onto a highly reflective slide, and spectra were collected using IRMS. Spectra were analyzed using multivariate statistical modeling to differentiate groups. Aliquots of samples also were subjected to metabolomic analysis. IRMS separated subjects into classes based on spectral information with no misclassifications among FM and RA or OA patients. Interclass distances of 15.4 (FM vs. RA), 14.7 (FM vs. OA) and 2.5 (RA vs. OA) among subjects, demonstrating the ability of IRMS to achieve reliable resolution of unique spectral patterns specific to FM. Metabolomic analysis revealed that RA and OA groups were metabolically similar, whereas biochemical differences were identified in the FM that were quite distinctive from those found in the other two groups. Both IRMS and metabolomic analysis identified changes in tryptophan catabolism pathway that differentiated patients with FM from those with RA or OA.
  2. Bob

    Bob

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    Ohio University Press Release:
    Faster, Simpler Diagnosis for Fibromyalgia May be on the Horizon
    July 2013
    http://medicalcenter.osu.edu/mediar...-for-Fibromyalgia-May-be-on-the-Horizon-.aspx


    Related news items.

    Faster, Simpler Diagnosis for Fibromyalgia May Be On the Horizon
    July 2013
    http://www.sciencedaily.com/releases/2013/07/130723134255.htm

    Researchers develop reliable way to use finger-stick blood sample to detect fibromyalgia syndrome
    July 2013
    http://www.news-medical.net/news/20...d-sample-to-detect-fibromyalgia-syndrome.aspx (Don't miss the second page, here.)

    Simple Blood Test May One Day Quickly Diagnose Fibromyalgia
    http://scicraze.blogspot.co.uk/2013/07/simple-blood-test-may-one-day-quickly.html#.UfA1lY2sjTo
  3. Bob

    Bob

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  4. Sea

    Sea Senior Member

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    Looks interesting Bob. I wonder how useful it will be for those who have both Fibro and OA (which I have and which I think is fairly common). Or Fibro and anything else really. I'm surprised they didn't look at any healthy matched controls.
  5. Bob

    Bob

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    Yes, it's a shame that they didn't include some healthy controls, but I think it was good practise to include other illnesses with similar symptoms. And it was only an initial study, so they will hopefully now carry out a larger study, with a wider range of controls. It's an interesting question about having both Fibro and OA. I imagine that individual spectroscopy patterns for both conditions would show up, overlapping. So, my guess is that if they were looking out for overlapping patterns then they should be able to identify both conditions. But I'm just guessing.
  6. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    The patent referred to above can be read here:

    http://www.google.com/patents/US8309931

    What puzzles me is that the term 'functional syndrome' is clearly being used to refer to physical, non-psychiatric conditions in this case, yet is used to mean psychosomatic by psychoquacks, synonymously with, among other terms, functional somatic syndromes, e.g. here:

    http://www.impact.arq.org/doc/kennisbank/1000010394-1.pdf
    Bob likes this.
  7. Bob

    Bob

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    Yes, it's quite ironic to be promoting a blood test for a 'functional syndrome'. Maybe the author is aware of the irony? It seems like they are sort of sticking two fingers up at the term 'functional syndrome'. I don't know if it's intentional or not.
    MeSci likes this.
  8. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    I have had cats with the 'functional syndrome' of interstitial cystitis. I wonder why the vet never just told the cats to pull themselves together? Maybe that's what I should do with the little lady who is my avatar, instead of giving her a supplement that she clearly isn't keen on taking. :D
  9. Valentijn

    Valentijn Activity Level: 3

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    These words originally had nothing to do with psychology ... but every time patients figure out that a term means "psychosomatic nutcase" the quacks have to come up with new terminology. It's just another method of deceit, which has the unfortunate effect of creating confusion when the terms are used in their original and legitimate context.
    Bob likes this.

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