now I'm pretty possitive the menningitis started as a sterle inflammatory menningitis that lead to CSF leaks but fairly quickly became infected because I was living in a high moister water damaged home and what made it even worse was that it had been halfass remodeled in a attempt to hide the problem which added to the mix many chemicals offgassing from the materials used.
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Fibromyalgia Imaging Study Shows Unique Brain Connectivity
- Thread starter osisposis
- Start date
Medscape Medical News
Fibromyalgia Brain Misreads Pleasure/Pain Signals
Janis C. Kelly
November 05, 2013
"I think the main message clinically is that there are prominent central changes in pain processing and that the preponderance of evidence is that this is a central nervous system disease," Daniel J. Clauw, MD, told Medscape Medical News. Dr. Clauw, who was not involved in this study, is professor of anesthesiology, medicine (rheumatology), and psychiatry and is also director of the Chronic Pain and Fatigue Research Center at the University of Michigan in Ann Arbor.
http://www.medscape.com/viewarticle/813851
Fibromyalgia Brain Misreads Pleasure/Pain Signals
Janis C. Kelly
November 05, 2013
"I think the main message clinically is that there are prominent central changes in pain processing and that the preponderance of evidence is that this is a central nervous system disease," Daniel J. Clauw, MD, told Medscape Medical News. Dr. Clauw, who was not involved in this study, is professor of anesthesiology, medicine (rheumatology), and psychiatry and is also director of the Chronic Pain and Fatigue Research Center at the University of Michigan in Ann Arbor.
http://www.medscape.com/viewarticle/813851
Fibromyalgia and the Brain: New Clues Reveal How Pain and Therapies are Processed
http://www.prohealth.com/library/showarticle.cfm?libid=17699
Friday, March 08, 2013
Pain Medicine News - µ-Opioid Receptors Impaired in Fibromyalgia Patients, Study Shows
A negative correlation was seen between the change in blood oxygenation level–dependent (BOLD) signal and the μ-opioid receptor binding in several regions of the brain involved in processing and controlling pain. These included the right posterior insula (R= –0.82; P=0.0004), left medial insula (R= –0.82; P=0.0003), left orbital frontal cortex (R= –0.75; P=0.0004) and right amygdala (R= –0.68; P=0.002).
Positive correlations also were found in the right dorsolateral prefrontal cortex (R=0.66;P=0.003), posterior cingulate (R=0.62; P=0.006) and the right putamen (R=0.72; P=0.0008).
"When opioid receptor binding went down, the evoked brain pain response went up in key brain regions that are involved in pain processing, such as the insula and amygdala," Dr. Harris said. He proposed two possible explanations: either the receptors were downregulated or activating the receptors actually caused pain.
http://psychologyofpain.blogspot.com/2013/03/pain-medicine-news-opioid-receptors.html
http://www.prohealth.com/library/showarticle.cfm?libid=17699
Friday, March 08, 2013
Pain Medicine News - µ-Opioid Receptors Impaired in Fibromyalgia Patients, Study Shows
A negative correlation was seen between the change in blood oxygenation level–dependent (BOLD) signal and the μ-opioid receptor binding in several regions of the brain involved in processing and controlling pain. These included the right posterior insula (R= –0.82; P=0.0004), left medial insula (R= –0.82; P=0.0003), left orbital frontal cortex (R= –0.75; P=0.0004) and right amygdala (R= –0.68; P=0.002).
Positive correlations also were found in the right dorsolateral prefrontal cortex (R=0.66;P=0.003), posterior cingulate (R=0.62; P=0.006) and the right putamen (R=0.72; P=0.0008).
"When opioid receptor binding went down, the evoked brain pain response went up in key brain regions that are involved in pain processing, such as the insula and amygdala," Dr. Harris said. He proposed two possible explanations: either the receptors were downregulated or activating the receptors actually caused pain.
http://psychologyofpain.blogspot.com/2013/03/pain-medicine-news-opioid-receptors.html
Theory of Mind and Emotional Functioning in Fibromyalgia Syndrome: An Investigation of the Relationship between Social Cognition and Executive Function
Marialaura Di Tella,
Lorys Castelli ,
Fabrizio Colonna,
Enrico Fusaro,
Riccardo Torta,
Rita B. Ardito,
Mauro Adenzato
PLOS
Published: January 16, 2015
DOI: 10.1371/journal.pone.0116542
The hyperactivity of the pain network due to central nervous system sensitisation, may lead to an increased demand on structures such as the amygdala and insula, reducing the available resources for other functions such as emotional processing.
http://www.ncbi.nlm.nih.gov/pubmed/25594169
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116542
Best Pract Res Clin Rheumatol. 2011 Apr;25(2):271-84. doi: 10.1016/j.berh.2011.02.003.
Neuroimaging of fibromyalgia.
Gracely RH1, Ambrose KR.
Author information
Abstract
The primary symptom of fibromyalgia is widespread pain. This symptom is accompanied by secondary symptoms, such as cognitive difficulties and sensitivity to painful stimulation, and by numerous co-morbidities. The first neuroimaging studies addressed the primary symptom by examining differences between patients and controls using single-photon-emission-computed tomography (SPECT). Subsequent studies focussed on the secondary symptom of increased sensitivity to painful stimulation. Functional MRI (fMRI) studies using the blood-oxygen-level-dependent (BOLD) method to assess brain activation demonstrated augmented sensitivity to painful pressure and the association of this augmentation with variables such as depression and catastrophising. These studies have also assessed brain processes associated with cognitive dysfunction. Neuroimaging studies of fibromyalgia have now come full circle, using new techniques to provide information about differences that may relate to underlying mechanisms and the primary symptom of widespread pain. Using a wide array of techniques, these studies have found differences in opioid receptor binding, concentration of metabolites associated with neural processing in pain-related regions and differences in functional brain networks and in regional brain volume and in white-matter tracks. This array of neuroimaging techniques continues to provide increasing information about supraspinal mechanisms associated with fibromyalgia that will aid in diagnosis, including identification of diagnostic subgroups, the development of new efficacious treatments that address both causes and symptoms and the matching of patients to treatments.
http://www.ncbi.nlm.nih.gov/pubmed/22094201
Curr Pain Headache Rep. 2012 Oct;16(5):388-98. doi: 10.1007/s11916-012-0284-9.
Brain imaging in fibromyalgia.
Jorge LL1, Amaro E Jr.
Author information
Abstract
Fibromyalgia is a primary brain disorder or a result of peripheral dysfunctions inducing brain alterations, with underlying mechanisms that partially overlap with other painful conditions. Although there are methodologic variations, neuroimaging studies propose neural correlations to clinical findings of abnormal pain modulation in fibromyalgia. Growing evidences of specific differences of brain activations in resting states and pain-evoked conditions confirm clinical hyperalgesia and impaired inhibitory descending systems, and also demonstrate cognitive-affective influences on painful experiences, leading to augmented pain-processing. Functional data of neural activation abnormalities parallel structural findings of gray matter atrophy, alterations of intrinsic connectivity networks, and variations in metabolites levels along multiple pathways. Data from positron-emission tomography, single-photon-emission-computed tomography, blood-oxygen-level-dependent, voxel-based morphometry, diffusion tensor imaging, default mode network analysis, and spectroscopy enable the understanding of fibromyalgia pathophysiology, and favor the future establishment of more tailored treatments.
http://www.ncbi.nlm.nih.gov/pubmed/22717698
cITED
http://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_citedin&from_uid=22094201
Marialaura Di Tella,
Lorys Castelli ,
Fabrizio Colonna,
Enrico Fusaro,
Riccardo Torta,
Rita B. Ardito,
Mauro Adenzato
PLOS
Published: January 16, 2015
DOI: 10.1371/journal.pone.0116542
The hyperactivity of the pain network due to central nervous system sensitisation, may lead to an increased demand on structures such as the amygdala and insula, reducing the available resources for other functions such as emotional processing.
http://www.ncbi.nlm.nih.gov/pubmed/25594169
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116542
Best Pract Res Clin Rheumatol. 2011 Apr;25(2):271-84. doi: 10.1016/j.berh.2011.02.003.
Neuroimaging of fibromyalgia.
Gracely RH1, Ambrose KR.
Author information
Abstract
The primary symptom of fibromyalgia is widespread pain. This symptom is accompanied by secondary symptoms, such as cognitive difficulties and sensitivity to painful stimulation, and by numerous co-morbidities. The first neuroimaging studies addressed the primary symptom by examining differences between patients and controls using single-photon-emission-computed tomography (SPECT). Subsequent studies focussed on the secondary symptom of increased sensitivity to painful stimulation. Functional MRI (fMRI) studies using the blood-oxygen-level-dependent (BOLD) method to assess brain activation demonstrated augmented sensitivity to painful pressure and the association of this augmentation with variables such as depression and catastrophising. These studies have also assessed brain processes associated with cognitive dysfunction. Neuroimaging studies of fibromyalgia have now come full circle, using new techniques to provide information about differences that may relate to underlying mechanisms and the primary symptom of widespread pain. Using a wide array of techniques, these studies have found differences in opioid receptor binding, concentration of metabolites associated with neural processing in pain-related regions and differences in functional brain networks and in regional brain volume and in white-matter tracks. This array of neuroimaging techniques continues to provide increasing information about supraspinal mechanisms associated with fibromyalgia that will aid in diagnosis, including identification of diagnostic subgroups, the development of new efficacious treatments that address both causes and symptoms and the matching of patients to treatments.
http://www.ncbi.nlm.nih.gov/pubmed/22094201
Curr Pain Headache Rep. 2012 Oct;16(5):388-98. doi: 10.1007/s11916-012-0284-9.
Brain imaging in fibromyalgia.
Jorge LL1, Amaro E Jr.
Author information
Abstract
Fibromyalgia is a primary brain disorder or a result of peripheral dysfunctions inducing brain alterations, with underlying mechanisms that partially overlap with other painful conditions. Although there are methodologic variations, neuroimaging studies propose neural correlations to clinical findings of abnormal pain modulation in fibromyalgia. Growing evidences of specific differences of brain activations in resting states and pain-evoked conditions confirm clinical hyperalgesia and impaired inhibitory descending systems, and also demonstrate cognitive-affective influences on painful experiences, leading to augmented pain-processing. Functional data of neural activation abnormalities parallel structural findings of gray matter atrophy, alterations of intrinsic connectivity networks, and variations in metabolites levels along multiple pathways. Data from positron-emission tomography, single-photon-emission-computed tomography, blood-oxygen-level-dependent, voxel-based morphometry, diffusion tensor imaging, default mode network analysis, and spectroscopy enable the understanding of fibromyalgia pathophysiology, and favor the future establishment of more tailored treatments.
http://www.ncbi.nlm.nih.gov/pubmed/22717698
cITED
http://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_citedin&from_uid=22094201
Janis C. Kelly
Medscape Medical News
Fibromyalgia Brain Misreads Pleasure/Pain Signals
November 05, 2013
"I think the main message clinically is that there are prominent central changes in pain processing and that the preponderance of evidence is that this is a central nervous system disease," Daniel J. Clauw, MD, told Medscape Medical News. Dr. Clauw, who was not involved in this study, is professor of anesthesiology, medicine (rheumatology), and psychiatry and is also director of the Chronic Pain and Fatigue Research Center at the University of Michigan in Ann Arbor.
http://www.medscape.com/viewarticle/813851
or here
http://www.medscape.com/index/list_3413_0
or put this in search
Medscape Medical News
Fibromyalgia Brain Misreads Pleasure/Pain Signals
sorry, didn't realize link didn't work before
Medscape Medical News
Fibromyalgia Brain Misreads Pleasure/Pain Signals
November 05, 2013
"I think the main message clinically is that there are prominent central changes in pain processing and that the preponderance of evidence is that this is a central nervous system disease," Daniel J. Clauw, MD, told Medscape Medical News. Dr. Clauw, who was not involved in this study, is professor of anesthesiology, medicine (rheumatology), and psychiatry and is also director of the Chronic Pain and Fatigue Research Center at the University of Michigan in Ann Arbor.
http://www.medscape.com/viewarticle/813851
or here
http://www.medscape.com/index/list_3413_0
or put this in search
Medscape Medical News
Fibromyalgia Brain Misreads Pleasure/Pain Signals
sorry, didn't realize link didn't work before
CSF rhinorrhea refers to a condition in which cerebrospinal fluid ("brain fluid") leaks through the nose.
The fluid is usually clear and watery,
unlike mucus in the nose which is thicker in consistency.
http://www.northwestsinuscenter.com/csf-leak-repair.html
CSF Leak
Cerebrospinal fluid (CSF) is a colorless fluid that cushions the brain, protecting it from mechanical trauma and infections.
Nasal CSF leaks are caused by small, sometimes microscopic breaks in the barrier between the brain and roof of the sinuses.
The diagnosis can be difficult to make because nasal drainage is also caused by allergies, sinusitis,
and other inflammatory conditions.
Causes of CSF leak include head injuries and prior head or sinus surgery.
http://www.ent.uci.edu/clinical-specialties/rhinology/csf-leak
I guess I should have posted these other links on Fibromyalgia separately, doesn't appear anyone is seeing them but they are worth seeing!!
Woolie
Senior Member
- Messages
- 3,263
No problems @osisposis, I'm reading them with interest. Just honouring my promise not to post further, because you were upset last time. And I don't want to upset you, sounds like you're having enough of a hard time already!